| Zhu Yanmei,Liang Shanshan,Wang Ruoyu,et al.Application and progress of patient-derived organoids in tumor radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2026,46(7):721-730 |
| Application and progress of patient-derived organoids in tumor radiotherapy |
| Received:January 14, 2026 |
| DOI：10.3760/cma.j.cn112271-20260114-00009 |
| KeyWords:Patient-derived organoids Radiotherapy Comprehensive treatment Individualized treatment |
| FundProject:辽宁省科技计划联合计划(技术攻关计划项目)(2024JH2/102600067) |
| Author Name | Affiliation | E-mail | | Zhu Yanmei | Key Laboratory of Biomarker High Throughput Screening and Target Translation for Breast and Gastrointestinal Tumors, Cancer Center, Zhongshan Hospital Affiliated to Dalian University, Dalian 116001, China | | | Liang Shanshan | Key Laboratory of Biomarker High Throughput Screening and Target Translation for Breast and Gastrointestinal Tumors, Cancer Center, Zhongshan Hospital Affiliated to Dalian University, Dalian 116001, China | | | Wang Ruoyu | Key Laboratory of Biomarker High Throughput Screening and Target Translation for Breast and Gastrointestinal Tumors, Cancer Center, Zhongshan Hospital Affiliated to Dalian University, Dalian 116001, China | | | Wang Zhe | Key Laboratory of Biomarker High Throughput Screening and Target Translation for Breast and Gastrointestinal Tumors, Cancer Center, Zhongshan Hospital Affiliated to Dalian University, Dalian 116001, China | wangzhe@dlu.edu.cn |
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| Abstract:: |
| Radiotherapy serves as a cornerstone in the comprehensive management of malignant tumors. However, clinical efficacy is often compromised by inherent radioresistance, inter-individual heterogeneity in radiosensitivity, and collateral damage to adjacent healthy tissues. Conventional preclinical models, such as two-dimensional cell lines and animal-derived xenograft tumors, exhibit significant limitations in recapitulating the tumor heterogeneity and microenvironmental fidelity of human tumors, thereby impeding the efficient translation of preclinical findings into clinical practice. Patient-derived organoids (PDOs), as a novel three-dimensional in vitro paradigm, have emerged as a robust platform due to their ability to highly preserve parental genomic landscapes, histological architectures, and microenvironmental gradients. This review systematically summarizes the multifaceted applications of PDOs technology across four domains: modeling patient radiosensitivity, elucidating mechanisms of radioresistance, assessing radiotherapy-induced adverse effects, and evaluating combination therapies. Furthermore, the review analyzes the current limitations and challenges inherent in PDOs-based research and offers perspectives on their application prospects in oncology and precision medicine, aiming to provide a solid theoretical foundation for the investigation and application of PDOs in related fields. |
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