| Li Dongliang,Lu Shun,Wang Jianxin,et al.Antitumor efficacy and safety of ultra-high dose rate spatially fractional radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2026,46(7):650-655 |
| Antitumor efficacy and safety of ultra-high dose rate spatially fractional radiotherapy |
| Received:July 15, 2025 |
| DOI：10.3760/cma.j.cn112271-20250715-00251 |
| KeyWords:Ultra-high dose rate irradiation Spatially fractionated radiotherapy Antitumor Safety |
| FundProject:四川省自然科学基金(2025ZNSFSC0787);四川省科技计划项目(2024ZDZX0027);成都市科技计划项目(2024-YF05-02201-SN);四川省博士后科研项目专项资金项目(TB2022090) |
| Author Name | Affiliation | E-mail | | Li Dongliang | School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China
Department of Radiation Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China | | | Lu Shun | Department of Radiation Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China | | | Wang Jianxin | Institute of Applied Electronics, CAEP, Mianyang 621900, China
National Key Laboratory on Advanced Laser and High Power Microwave, Mianyang 621900, China | | | Li Lintao | Department of Radiation Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China | | | Shen Yufeng | School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China
Department of Radiation Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China | | | Wu Zheyao | School of Medicine, University of Electronic Science and Technology of China, Chengdu 610054, China
Department of Radiation Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China | | | Zhou Jie | Department of Radiation Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital and Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu 610041, China | 506468282@qq.com |
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| Abstract:: |
| Objective To establish a model of ultra-high dose rate spatially fractionated radiotherapy (FLASH-SFRT), and to preliminarily evaluate its antitumor efficacy and safety in comparison with conventional dose rate radiotherapy (CONV-RT) and SFRT.Methods A lead block was fabricated to allow electron beams passed through and form peak and valley doses. BALB/c mice were injected with 4T1 breast cancer cell suspension at the thigh root. Two weeks later, mice were randomly divided into 4 groups (n=6 per group) The CONV-RT group received irradiation at 0.5 Gy/s with a total dose of 5 Gy. The SFRT and FLASH-SFRT groups were irradiated at 0.5 Gy/s and 200 Gy/s, respectively, with an average dose of 5 Gy. The control group received tumor inoculation additional treatment. After irradiation, the tumor volume and mice body weight were measured daily Tumors were harvested, measured, and weighed 2 weeks later. For safety evaluation, 24 mice were grouped and irradiated as above and observed continuously for 12 days. Results At an average dose of 5 Gy SFRT and FLASH-SFRT, the peak dose was 15 Gy, valley dose was 2 Gy, and the peak-to-valley ratio was approximately 7.5. On day 6 post-irradiation, the tumor volumes in the CONV-RT group [(483.7±115.1) mm3], SFRT group [(438.8±105.4) mm3], and FLASH-SFRT group [(405.0±98.0 mm3)] were significantly lower than in the control group [(807.3±65.8) mm3] (t=5.46, 6.11, 7.62, P<0.05), with no significant differences among three radiotherapy groups (P>0.05). Notably, on day 12 post-irradiation, the tumor volume in the FLASH-SFRT group [(931.7±243.3) mm3] was significantly lower than in the CONV-RT group [(1 246.3±240.1) mm3, t=2.26, P<0.05]. The safety assessment revealed no obvious skin and bone marrow injury in any of the four radiation groups. Conclusion FLASH-SFRT and SFRT exhibit significant antitumor efficacy compared with CONV-RT. |
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