| Wang Yuanxu,Tang Yufeng.Advances in research on biological effects of FLASH-RT and CONV-RT on radiation-induced brain injury[J].Chinese Journal of Radiological Medicine and Protection,2026,46(6):636-640 |
| Advances in research on biological effects of FLASH-RT and CONV-RT on radiation-induced brain injury |
| Received:June 01, 2025 |
| DOI：10.3760/cma.j.cn112271-20250601-00185 |
| KeyWords:Radiation-induced brain injury|FLASH irradiation|Biological effect |
| FundProject:四川省卫生健康委员会科技项目(24CXTD15) |
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| Abstract:: |
| Radiotherapy represents a primary treatment modality for head and neck malignant tumors. However, the resulting radiation-induced brain injury (RIBI) significantly reduces patients' quality of life (QoL), for which there is a lack of effective preventive measures presently. In recent years, many novel approaches in radiotherapy have emerged, aimed at reducing RIBI. Among these, ultra-high dose rate radiotherapy (FLASH-RT) has attracted widespread attention as it can maintain the inhibitory effect on tumor tissues while also minimizing radiation damage to normal tissues. Based on a review of relevant literature from China or abroad, this study presents a comparison between the biological effects of FLASH and conventional radiotherapy (CONV-RT) on RIBI and explores possible mechanisms by which FLASH irradiation alleviates RIBI. These efforts are expected to provide a theoretical basis for the clinical translation of FLASH-RT. |
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