| Lin Hua,Li Li,Su Minggang,et al.Feasibility of Q.Clear reconstruction algorithm in reducing radiopharmaceutical dose for adrenal 68Ga-Pentixafor PET/MR imaging[J].Chinese Journal of Radiological Medicine and Protection,2026,46(5):458-463 |
| Feasibility of Q.Clear reconstruction algorithm in reducing radiopharmaceutical dose for adrenal 68Ga-Pentixafor PET/MR imaging |
| Received:February 25, 2026 |
| DOI：10.3760/cma.j.cn112271-20260225-00063 |
| KeyWords:Q.Clear PET/MR Adrenal gland Radiopharmaceutical dose Image reconstruction |
| FundProject:国家重点研发计划项目(2023YFC2414201-1) |
| Author Name | Affiliation | E-mail | | Lin Hua | Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China | | | Li Li | Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China | | | Su Minggang | Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu 610041, China | | | Hu Yunlong | Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China | | | Peng Wanlin | Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China | | | Li Zhenlin | Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China | | | Xia Chunchao | Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China | xiachunchao@wchscu.cn |
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| Abstract:: |
| Objective To explore the feasibility of Bayesian penalized likelihood reconstruction algorithm (Q.Clear) combined with low-dose radiopharmaceuticals in adrenal gallium-68-pentixafor positron emission tomography/magnetic resonance (68Ga-Pentixafor PET/MR), in comparison with ordered subset expectation maximization (OSEM) algorithm, in terms of image quality and radiation dose. Methods A total of 35 patients with primary aldosteronism who underwent 68Ga-Pentixafor PET/MR at West China Hospital of Sichuan University were retrospectively enrolled. The mean injected dose was (142.3 ± 38.5) MBq. Data were acquired for 6 min per bed position and subsequently partitioned to simulate shorter acquisition times(1, 1.5, 2, 3, and 6 min/bed), corresponding to 16.7%, 25%, 33.3%, 50%, and 100% of the full dose, respectively. Images were reconstructed using both Q.Clear(β=1 000) and OSEM.Subjective assessments included image noise,lesion clarity,and overall image quality scores. Objective metrics encompassed standardized uptake values (SUVmax, SUVmean), lesion volume (LV), signal-to-noise ratio(SNR), lesion-to-background ratio(L/B) and background noise(SD). Results Subjective assessments showed that Q.Clear achieved diagnostic-quality images (score ≥3) in acquisition time groups of 2 min or longer;however, the 2 min-group exhibited increased noise compared to longer acquisitions. Analysis of objective parameters revealed superior noise suppression with Q.Clear across all time groups compared to OSEM(P<0.05)Notably, no significant differences were observed between Q.Clear at 2 min and OSEM at 6 min in SNR[60.50 (44.62, 86.97) vs.57.55 (39.26, 80.06)], L/B[11.17 (8.60, 15.72) vs.11.84 (7.23, 13.19)] or SD[0.24 (0.18, 0.34) vs. 0.28 (0.19, 0.35)]. Conclusions Maintaining a 6-minute acquisition time per bed position with 33.3% injected radiopharmaceutical dose and Q.Clear reconstruction provides sufficient image quality for clinical diagnosis.This finding supports the development of low-dose scanning protocols and contributes to radiation safety in precision diagnosis and treatment of adrenal tumors. |
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