| Liu Liting,Yang Siqi,Xia Jingqi,et al.Advances in research on pathogenesis and corresponding integrated prevention and control strategies for radiation enteritis[J].Chinese Journal of Radiological Medicine and Protection,2026,46(4):414-420 |
| Advances in research on pathogenesis and corresponding integrated prevention and control strategies for radiation enteritis |
| Received:September 06, 2025 |
| DOI：10.3760/cma.j.cn112271-20250906-00323 |
| KeyWords:Radiation enteritis|Pelvic and abdominal radiotherapy|Radiation-induced injury|Gut microbiota |
| FundProject:国家自然科学基金(82373207,12375341);哈尔滨医科大学肿瘤医院攀登基金(PDYS2024-06) |
| Author Name | Affiliation | E-mail | | Liu Liting | Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin 150040, China | | | Yang Siqi | Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin 150040, China | | | Xia Jingqi | Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin 150040, China | | | Liu Dongmei | Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin 150040, China | | | Ruan Yingwen | Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin 150040, China | | | Bai Yanling | Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin 150040, China | | | Yang Shanshan | Department of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin 150040, China | yangshanshan@hrbmu.edu.cn |
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| Abstract:: |
| Cancer remains the second leading cause of human death at present. Radiotherapy, a common treatment method for malignant tumors, tends to cause varying degrees of damage to the surrounding normal tissues while effectively controlling tumors. After radiotherapy, 80% of patients with pelvic and abdominal malignancies experience acute/chronic gastrointestinal complications. In severe cases, these complications lead to radiotherapy interruption, elevate the possibility of tumor recurrence, and even affect the long-term quality of life of the patients. Therefore, radiation enteritis (RE) has emerged as an important factor limiting the efficacy and safety of radiotherapy. In recent years, an increasing number of insights into molecular radiobiology and intestinal microecology have shed light on the pathogenesis of RE. It has been revealed that the occurrence of RE involves several critical processes: damage to the intestinal epithelial barrier, imbalanced immune homeostasis, dysregulated accumulation of reactive oxygen species, and disordered intestinal flora structure. Currently, despite the continuous evolution of prevention and treatment strategies for RE, there remains a lack of consensus on them. This study reviews the advances in research on the pathogenesis of RE and corresponding comprehensive prevention and treatment strategies. The purpose is to provide a theoretical basis and practical ideas for improving both the clinical safety of radiotherapy for pelvic and abdominal tumors and the quality of life of the patients. |
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