| Yang Yinyin,Xu Ruizhe,Yang Hailing,et al.Survival and quality of life of pediatric patients with intracranial ependymoma undergoing postoperative adjuvant radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2026,46(2):192-197 |
| Survival and quality of life of pediatric patients with intracranial ependymoma undergoing postoperative adjuvant radiotherapy |
| Received:January 23, 2025 |
| DOI：10.3760/cma.j.cn112271-20250123-00033 |
| KeyWords:Ependymoma Radiotherapy Survival Quality of life (QoL) |
| FundProject:江苏省卫生健康委员会科研项目(JSDW202236);苏州市科技计划(医疗卫生科技创新)项目(SKY2022167) |
| Author Name | Affiliation | E-mail | | Yang Yinyin | Department of Radiotherapy and Oncology, Second Affiliated Hospital of Soochow University, Clinical Medical Center for Radiotherapy of Suzhou, Suzhou 215004, China | | | Xu Ruizhe | Department of Radiotherapy and Oncology, Second Affiliated Hospital of Soochow University, Clinical Medical Center for Radiotherapy of Suzhou, Suzhou 215004, China | | | Yang Hailing | Department of Neurosurgery, Children's Hospital of Soochow University, Suzhou 215003, China | | | Liu Chang | Department of Radiotherapy and Oncology, Second Affiliated Hospital of Soochow University, Clinical Medical Center for Radiotherapy of Suzhou, Suzhou 215004, China | | | Huang Yingyi | Department of Radiotherapy and Oncology, Second Affiliated Hospital of Soochow University, Clinical Medical Center for Radiotherapy of Suzhou, Suzhou 215004, China | | | Xing Pengfei | Department of Radiotherapy and Oncology, Second Affiliated Hospital of Soochow University, Clinical Medical Center for Radiotherapy of Suzhou, Suzhou 215004, China | | | Tian Ye | Department of Radiotherapy and Oncology, Second Affiliated Hospital of Soochow University, Clinical Medical Center for Radiotherapy of Suzhou, Suzhou 215004, China | dryetian@126.com |
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| Abstract:: |
| Objective To explore the survival status and prognostic factors of pediatric patients with intracranial ependymoma (EPEN) following postoperative radiotherapy and analyze their quality of life (QoL). Methods A retrospective analysis was conducted on the clinical data of 29 EPEN children who were treated in the Department of Radiotherapy and Oncology of the Second Affiliated Hospital of Soochow University from November 2012 to November 2023. Their 5-year overall survival (OS) and progression-free survival (PFS) were analyzed using the Kaplan-Meier method, and the factors affecting their OS and PFS were assessed through the log-rank test. The QoL of the surviving patients was evaluated from three aspects: growth and development conditions, the ability to perform activities of daily living (ADL), and social role assuming. Results The 29 EPEN patients exhibited a 5-year OS and PFS of 84.5% and 60.2%, respectively. Among these, 11 patients suffered from recurrence following radiotherapy, with a median OS of 56 months (range: 18-120 months). Univariate analysis identified several risk factors affecting the PFS, including an age of less than three years, incomplete tumor resection, and a Ki-67 index of 20% or higher (χ2=4.89, 8.44, 5.13, P<0.05). Additionally, body mass index (BMI) assessment was performed among the 25 survivors, revealing that eight were moderately underweight, two were overweight, and the remaining 15 had a normal BMI. The ADL assessment using the Wee functional independence measure (WeeFIM) indicated that 20 patients received a total WeeFIM score of 126 each, four patients scored over 108, and one received a total WeeFIM score of 49. For social role assuming, six patients experienced school suspensions for 1-3 years, while two patients faced challenges in adjusting to school. In contrast, despite average or poor academic performance, a total of 12 patients did not suffer from any communication barriers. Conclusions For pediatric patients with EPEN, postoperative radiotherapy achieves relatively high OS; however, the recurrence rate remains high. Factors affecting their PFS include age, the extent of surgical resection, and the Ki-67 expression. Most of the EPEN survivors have acceptable QoL, which warrants increasing attention in the future. |
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