| Xin Caixia,Zhang Guorong.Advances in research on stereotactic radiosurgery combined with targeted therapy for brain metastases from driver gene-positive non-small cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2025,45(12):1272-1278 |
| Advances in research on stereotactic radiosurgery combined with targeted therapy for brain metastases from driver gene-positive non-small cell lung cancer |
| Received:June 06, 2025 |
| DOI：10.3760/cma.j.cn112271-20250606-00195 |
| KeyWords:Stereotactic radiosurgery (SRS) Non-small cell lung cancer (NSCLC) Brain metastases (BM) Molecular targeted therapy |
| FundProject:内蒙古自治区关键技术攻关项目(2021GG0205) |
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| Abstract:: |
| For patients with advanced non-small cell lung cancer (NSCLC), brain metastases (BM) represent the complication with the highest lethality. Patients with driver gene-positive NSCLC, especially those with epidermal growth factor receptor (EGFR) gene mutations, are more prone to suffer from BM. The occurrence and progression of BM seriously affect the quality of life and prognosis of these patients. The emergence of molecular targeted drugs contributes to more individualized and precise treatment for BM as a complication of NSCLC. Meanwhile, stereotactic radiosurgery (SRS) has become the most important therapy for the local treatment of BM from NSCLC. The combination of targeted therapy and SRS has become a hot research topic since the synergistic effects of both can improve the prognosis of driver gene-positive NSCLC patients with BM. However, for patients with asymptomatic BM, the optimal intervention timing of SRS remains controversial. This literature review presents the strategy and relevant research progress of SRS combined with targeted therapy for BM from driver gene-positive NSCLC in recent years. |
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