| Zhang Yi,Yang Yiwei,Tang Yinghong,et al.A study and application of rapid and precise dose measurement based on Gafchromic EBT4 film in FLASH radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2025,45(11):1144-1151 |
| A study and application of rapid and precise dose measurement based on Gafchromic EBT4 film in FLASH radiotherapy |
| Received:July 10, 2025 |
| DOI：10.3760/cma.j.cn112271-20250710-00246 |
| KeyWords:FLASH radiotherapy EBT film RGB value Net optical density |
| FundProject:国家自然科学基金(12375318);贵州省抗癌协会科技计划项目([2023]015) |
| Author Name | Affiliation | E-mail | | Zhang Yi | Department of Oncology, Affiliated Hospital of Guizhou Medical University & Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550024, China | | | Yang Yiwei | Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang 621900, China | | | Tang Yinghong | College of Nuclear Technology and Automation Engineering, Chengdu University of Technology, Chengdu 610000, China | | | Wang Shilan | Institute of Applied Electronics, China Academy of Engineering Physics, Mianyang 621900, China | | | Wu Peng | Department of Electrical Control and Clinical, Zhongjiu Flash Medical Technology Co., Ltd., Mianyang 621000, China | | | Yang qin | Department of Electrical Control and Clinical, Zhongjiu Flash Medical Technology Co., Ltd., Mianyang 621000, China | | | Huang Xufan | Department of Electrical Control and Clinical, Zhongjiu Flash Medical Technology Co., Ltd., Mianyang 621000, China | | | Luo Yin | Department of Electrical Control and Clinical, Zhongjiu Flash Medical Technology Co., Ltd., Mianyang 621000, China | | | Jiang Yu | Department of Electrical Control and Clinical, Zhongjiu Flash Medical Technology Co., Ltd., Mianyang 621000, China | | | Luo Wenjun | Department of Electrical Control and Clinical, Zhongjiu Flash Medical Technology Co., Ltd., Mianyang 621000, China | | | Zou Guiqiang | Department of Electrical Control and Clinical, Zhongjiu Flash Medical Technology Co., Ltd., Mianyang 621000, China | | | Feng Hua | Department of Electrical Control and Clinical, Zhongjiu Flash Medical Technology Co., Ltd., Mianyang 621000, China | | | Hu Yinxiang | Department of Oncology, Affiliated Hospital of Guizhou Medical University & Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550024, China
School of Clinical Medical, Guizhou Medical University, Guiyang 550000, China | hyx_wengan@163.com |
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| Abstract:: |
| Objective To establish a rapid and precise dose measurement method with EBT4 film and ensure its measurement accuracy to be within the required range through strict operational procedures for the purpose of addressing the two essential issues of poor measurement accuracy and timeliness of EBT film under FLASH conditions. Methods After storing under different humidity conditions for a certain period of time, the film was exposed to radiation for analyzing the influence of air humidity on the intrinsic performance of EBT film. By means of repeated scanning operations and the film angle rotation, the influences of repeated scanning and film placement angle were analuzed. Parabolic correction method was used to reduce the spatial position influence during the scanning process. By analying the relationship between net optical density (netOD) and absorbed dose through the comparison of three fitting method, the optimal fitting curve was selected. After irradiation of the same batch of films for 5 min and 24 h, the film doses were calibrated and then compared with ionization chamber-measured result. The rapid and precise film dosimetry method was used to measure both the percentage depth dose from X-rays at ultra-high dose rate and the dose distribution at a depth of 2 cm in water. Results Air humidity had the greatest influence on the intrinsic performance of EBT film (approximately 20%). The average deviation of repeated scans is within 0.5%. The angle at which the film is placed significantly affected the readouts of the film with the maximum influence approximately 70%. The net optical density combined with polynomial fitting can control the fitting residuals of 1-16 Gy within 3%. The change rate of light channels at 5 min already mostly met the requirements of the rapid mode (< 0.5%). Compared with the measurement result obtained using the reference ionization chamber, the deviations of the 5 min or 24 h dose calibration curves were all within 2%. Conclusions The EBT4 film can be employed as a precise dosimeter to quickly measure the FLASH radiation dose. Rapid and precise FLASH dose measurements can meet the stringent requirements of both preclinical and clinical FLASH research. |
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