| Cao Zhifei,Du Xiaobo.FLASH radiotherapy: pioneering the revolutionary path from bench to bedside[J].Chinese Journal of Radiological Medicine and Protection,2025,45(11):1047-1051 |
| FLASH radiotherapy: pioneering the revolutionary path from bench to bedside |
| Received:September 16, 2025 |
| DOI：10.3760/cma.j.cn112271-20250916-00334 |
| KeyWords:FLASH Radiotherapy Ultra-high dose rate Tumors |
| FundProject:国家自然科学基金(12575369,12275192);中核集团青年英才项目 |
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| Abstract:: |
| Ultra-high dose rate radiotherapy (dose rate ≥40 Gy/s), spearheading a revolution in radiation oncology through its unique "FLASH effect", demonstrates remarkable efficacy in eradicating tumors while concomitantly mitigating damage to normal tissues. This special issue compiles cutting-edge research, offering multi-dimensional insights into its biological mechanisms. At the molecular level, FLASH achieves targeted tumor killing by differentially regulating endoplasmic reticulum stress, cell cycle arrest patterns, programmed cell death, and energy metabolism reprogramming. FLASH irradiation may induce a transient oxygen depletion, creating a hypoxic window that facilitates the efficient scavenging of free radicals within normal tissues. Various animal studies have consistently validated FLASH's capacity to significantly alleviate both acute and long-term radiation injuries while potently suppressing tumor growth. Concurrently, advancements in physics and dosimetry have addressed the core challenges of precise delivery and measurement of ultra-high dose rates, in order to clear critical hurdles for clinical translation. In summary, FLASH radiotherapy has established a solid foundation, spanning from mechanistic elucidation to technological innovation. Its clinical translation now urgently demands the advancement of high-quality, standardized research, with the ultimate goal of safely and precisely harnessing the highly promising FLASH effect for patient benefit, thereby achieving a transformative leap in both therapeutic efficacy and quality of life for cancer patients undergoing radiotherapy. |
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