| Hua Jianzhong,Dong Juancong,Dang Xuhong,et al.Application and progress of nanomaterials in the treatment of radiation injury[J].Chinese Journal of Radiological Medicine and Protection,2025,45(10):1032-1040 |
| Application and progress of nanomaterials in the treatment of radiation injury |
| Received:March 25, 2025 |
| DOI：10.3760/cma.j.cn112271-20250325-00108 |
| KeyWords:Nanomaterials Radiation injury Decorporation |
| FundProject:中核集团领创科研项目(JT23010201) |
| Author Name | Affiliation | E-mail | | Hua Jianzhong | China Institute for Radiation Protection, Taiyuan 030006, China | | | Dong Juancong | China Institute for Radiation Protection, Taiyuan 030006, China | | | Dang Xuhong | China Institute for Radiation Protection, Taiyuan 030006, China | | | Jia Xinran | China Institute for Radiation Protection, Taiyuan 030006, China | | | Yu Jinhuan | Center for Disease Control and Prevention of China-Rok (Changchun) International Cooperation Demonstration Zone, Changchun 130051, China | | | Liu Xiaoming | China Institute for Radiation Protection, Taiyuan 030006, China | lxmsxqx@163.com |
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| Abstract:: |
| The applications of nuclear technology in industries, medicine, and other fields have increased the risk of radiation injury. Although some small-molecule drugs for radiation injury treatment have been applied clinically or are in preclinical research, their therapeutic efficacy is significantly limited by short circulation time and rapid metabolism. Nanomaterials have attracted growing attention with their outstanding bioactivity, chemical stability, tissue compatibility, and targeted delivery capabilities, therefore having the promise of offering the potential solutions to the limitations of current small-molecule drugs. However, their biosafety and clinical efficacy require further investigation. This review summarizes the design strategies and classifications of nanomaterials for radiation injury treatment, analyzes current research progress in their therapeutic applications, and introduces nanomaterial-based approaches for enhancing the elimination of internal radionuclide contamination. Finally, the challenges and future prospects of nanomaterials in radiation injury treatment are discussed. This review aims to provide researchers with a comprehensive understanding of recent advances in nanomaterial-based radiation injury therapeutics, thereby promoting further development in this field. |
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