| Wang Difan,Cai Shang.Role of mitochondria in pathological changes of radiation-induced intestinal injury and advances in research on mitochondria as potential targets for prevention and treatment[J].Chinese Journal of Radiological Medicine and Protection,2025,45(10):1025-1031 |
| Role of mitochondria in pathological changes of radiation-induced intestinal injury and advances in research on mitochondria as potential targets for prevention and treatment |
| Received:December 23, 2024 |
| DOI：10.3760/cma.j.cn112271-20241223-00489 |
| KeyWords:Radiation-induced intestinal injury Mitochondria Reactive oxygen species Apoptosis Mitochondrial autophagy |
| FundProject:江苏省大学生创新创业训练计划项目(202310285167Y); 苏州医学院学生课外科研项目(2022YXYKWKY064) |
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| Abstract:: |
| Radiation-induced intestinal injury (RⅢ) is identified as a common complication of radiotherapy. However, there exists a lack of safe and effective treatment method. To address this issue, researchers have made great efforts to explore the mechanisms underlying RⅢ, revealing that mitochondria contribute to the pathological changes of RⅢ, with the mitochondria-mediated generation of reactive oxygen species (ROS), the regulation of apoptosis, and mitochondrial autophagy representing key processes. This review aims to elucidate the role of mitochondria in pathological changes of RⅢ and to introduce the progress of research on mitochondria as potential targets for RⅢ prevention and treatment. |
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