| Jia Xiaoxiao,Ji Kaihua,Zhang Manman,et al.Advances in research on the application of Lactobacillus and its engineered probiotics to the prevention and treatment of radiation-induced intestinal injury[J].Chinese Journal of Radiological Medicine and Protection,2025,45(10):1015-1024 |
| Advances in research on the application of Lactobacillus and its engineered probiotics to the prevention and treatment of radiation-induced intestinal injury |
| Received:October 28, 2024 |
| DOI：10.3760/cma.j.cn112271-20241028-00412 |
| KeyWords:Lactobacillus Probiotic function Radiation-induced injury Construction efficiency |
| FundProject:国家自然科学基金(32071241, 82103837) |
| Author Name | Affiliation | E-mail | | Jia Xiaoxiao | School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, China | | | Ji Kaihua | Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China | | | Zhang Manman | Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China | | | Liu Yingshuang | Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China | | | Li Jianguo | School of Basic Medical Sciences, Shandong Second Medical University, Weifang 261053, China | ljg7111@sdsmu.edu.cn | | Liu Qiang | Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China | |
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| Abstract:: |
| Intestinal radiosensitivity makes radiation-induced intestinal injury (RⅢ) as a common complication among individuals exposed to accidental radiation and patients with abdominal or pelvic malignancies receiving radiotherapy. At present, there are no effective measures for the prevention and treatment of RⅢ. Developing novel prevention and treatment strategies is of great significance for improving the prognosis and quality of life for both individuals exposed to accidental radiation and cancer patients. Lactobacillus, a Gram-positive bacterium, is widely observed in humans and animals. It exhibits notable probiotic functions, including maintaining gut microbiota homeostasis, preserving intestinal barrier, and modulating immune responses. Substantial studies have demonstrated that Lactobacillus has remarkable protective and therapeutic effects against radiation-induced injury, specifically significantly alleviating RⅢ. These probiotic functions of Lactobacillus make it have high priority to become the chassis of genetically engineered strains. However, multiple factors influence the construction of a genetically engineered strain, limiting the application of Lactobacillus as a chassis. This review focuses on the probiotic functions of Lactobacillus, highlighting advances in research on Lactobacillus and its engineered probiotics in radiation protection and treatment. Furthermore, it summarizes key factors influencing the construction of genetically engineered strains based on the Lactobacillus chassis. It aims to provide insights for developing genetically engineered strains with radioprotective and therapeutic effects using Lactobacillus as the chassis. |
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