| Wang Wenyu,Wei Ran,Yuan Siqi,et al.Assessment of clinal target volume deformation in online adaptive radiotherapy for prostate cancer[J].Chinese Journal of Radiological Medicine and Protection,2025,45(10):973-978 |
| Assessment of clinal target volume deformation in online adaptive radiotherapy for prostate cancer |
| Received:July 04, 2025 |
| DOI：10.3760/cma.j.cn112271-20250704-00223 |
| KeyWords:Online adaptive radiotherapy(OART) Intrafraction motion Target volume deformation Deformable point set registration Three-dimensional point cloud |
| FundProject:国家自然科学基金(12405406) |
| Author Name | Affiliation | E-mail | | Wang Wenyu | National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Wei Ran | National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Yuan Siqi | National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | | | Men Kuo | National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China | menkuo126@126.com |
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| Abstract:: |
| Objective To assess intrafractional errors of the deformation of clinical target volumes (CTVs) during online adaptive radiotherapy (OART) for prostate cancer patients, aiming to provide a basis for online plan optimization. Methods A retrospective analysis was conducted for 13 prostate cancer patients who received 1.5 T magnetic resonance imaging (MRI)-guided OART (8 Gy × 5 fractions, totaling 65 fractions) at the Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences. The MRI images were collected at the beginning and end of various treatment fractions. Then, the CTVs and organs at risk (OARs) were delineated by the same radiation oncologist. After rigid registration and triangle mesh generation, the surface vertices were extracted. The deformable registration for the CTV surfaces was performed using the thin-plate spline robust point matching (TPS-RPM) algorithm, yielding vertex correspondences. Last, both systematic and random intrafractional errors of CTV deformation were calculated. Results The average Hausdorff distance (HD) for deformable registration of treatment fractions was (1.68 ± 0.28) mm. The intrafractional systematic errors of CTV deformation were (0.25 ± 3.18) mm (anterior-posterior direction; A-P), (0.89 ± 3.85) mm (left-right direction, L-R), and (-1.98 ± 6.69) mm (superior-inferior direction, S-I). The intrafractional random errors of CTV deformation were determined at (-0.26 ± 1.89) mm (A-P), (-0.08 ± 0.88) mm (L-R), and (-0.04 ± 1.86) mm (S-I). Conclusions During OART, CTV deformations primarily occur in the S-I direction. Therefore, it is necessary to consider the expanded size of margins in this direction during OART for prostate cancer. |
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