| Wang Chenyang,Wang Shuo,Yang Jun,et al.Advances in research on spatially fractionated radiation therapy[J].Chinese Journal of Radiological Medicine and Protection,2025,45(9):925-933 |
| Advances in research on spatially fractionated radiation therapy |
| Received:April 09, 2025 |
| DOI：10.3760/cma.j.cn112271-20250409-00128 |
| KeyWords:Spatially fractionated radiation therapy (SFRT) Radiobiology Clinical application |
| FundProject:中央引导地方科技发展资金项目(科技创新基地项目246Z7707G) |
| Author Name | Affiliation | E-mail | | Wang Chenyang | Radiotherapy Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Wang Shuo | Radiotherapy Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Yang Jun | Department of Radiation Oncology, Foshan Fosun Chancheng Hospital, Foshan 528000, China | | | Wang Jun | Radiotherapy Department, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | wangjun0818@hebmu.edu.cn |
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| Abstract:: |
| Conventional radiotherapy tends to deliver uniform doses to tumors. However, to avoid high-dose-induced toxicity to surrounding organs or in the case of large-volume tumors, effective doses are frequently limited, thereby undermining the treatment efficacy. Spatially fractionated radiation therapy (SFRT) has the potential to overcome this limitation. Specifically, SFRT delivers spatially differential irradiation within target volumes, creating high-dose peak zones and low-dose trough zones. This uneven dose pattern may activate potential biological effects to kill tumor cells, improve the immune microenvironment, and activate the immune system. Besides, this pattern can reduce the dose to normal tissues surrounding large-volume tumors. This study provides a review of the development history, radiobiological mechanisms, relevant parameters, and clinical applications of SFRT, as well as its future trends. |
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