| Zhu Shen,Hu Bo,Cui Minghui,et al.Advances in research on mechanisms underlying damage of low-dose ionizing radiation to spermatogenesis and relevant protective measures[J].Chinese Journal of Radiological Medicine and Protection,2025,45(8):818-826 |
| Advances in research on mechanisms underlying damage of low-dose ionizing radiation to spermatogenesis and relevant protective measures |
| Received:September 24, 2024 |
| DOI：10.3760/cma.j.cn112271-20240924-00378 |
| KeyWords:Low dose of ionizing radiation Spermatogenesis Reactive oxygen species DNA repair Radiation protection |
| FundProject: |
| Author Name | Affiliation | E-mail | | Zhu Shen | Department of Radiation Safety and Occupational Health, Naval Medical Center of PLA, Shanghai 200433, China
Department of Medical Engineering, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai 200433, China | | | Hu Bo | Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Shanghai 200433, China | | | Cui Minghui | Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Shanghai 200433, China | | | Yu Haobing | Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Shanghai 200433, China | | | Liu Xiaoyu | Department of Marine Biomedicine and Polar Medicine, Naval Medical Center of PLA, Shanghai 200433, China | | | Liu Suiyi | Department of Medical Engineering, Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai 200433, China | | | He Ying | Department of Radiation Safety and Occupational Health, Naval Medical Center of PLA, Shanghai 200433, China | yinghe_hys@163.com |
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| Abstract:: |
| Ionizing radiation occurs not only during nuclear and radiological terrorist attacks or nuclear accidents but also in medical applications and daily life. In recent years, the potential toxic effects of low-dose ionizing radiation on the male reproductive system have raised public health concerns. Most specifically, for the testis, a highly sensitive target organ to ionizing radiation, there is an urgent need to determine the mechanisms underlying the association between radiation-induced spermatogenic failure and male infertility. Focusing on the potential injurious effects of low-dose ionizing radiation on spermatogenesis, this review presents a summary and analysis of various underlying mechanisms including oxidative stress, apoptosis, and DNA damage repair and reviews recent domestic and international strategies for protecting against radiation-induced reproductive system damage in order to offer references for future research on the injurious effects of low-dose radiation on spermatogenesis and relevant protection. |
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