| Qi Jiacheng,Zhuo Weihai,Li Junhao,et al.Research progress on internal dose estimation mehtods for radionuclide therapy[J].Chinese Journal of Radiological Medicine and Protection,2025,45(8):810-817 |
| Research progress on internal dose estimation mehtods for radionuclide therapy |
| Received:April 08, 2025 |
| DOI：10.3760/cma.j.cn112271-20250408-00127 |
| KeyWords:Radionuclide therapy In vivo imaging Pharmacokinetic model Internal radiation dose Dose-effect |
| FundProject:国家自然科学基金面上项目(12375308);国家市场监督管理总局科技创新人才计划(QNBJ202304) |
| Author Name | Affiliation | E-mail | | Qi Jiacheng | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | | Zhuo Weihai | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | whzhuo@fudan.edu.cn | | Li Junhao | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | | Wang Jinghang | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | |
|
| Hits: 313 |
| Download times: 171 |
| Abstract:: |
| Dose estimation of radiopharmaceutical therapy is essential for the accurate evaluation of its efficacy and safety, as well as for guiding subsequent clinical research. The dosimetry estimation process typically requires understanding of the in vivo spatial distribution and dynamic transportation of radionuclides, followed by calculation of the energy deposition in tumor target volume and organs at risk from ionizing radiation of varying types and energies released by accumulated radionuclides. This review focuses on advancements in the aforementioned research aspects and the relationship between internal radiation dose and biological effects. Furthermore, this review prospectively discusses future research directions, aiming to enhance comprehension of internal radiation dose estimation and provides theoretical frameworks and technical references for improving clinical evaluation accuracy in radiopharmaceutical therapy. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
