| Li Yingxu,Xu Xilong,Zhang Yanhai,et al.Development of adjustable spatial resolution cone beam CT for small animals[J].Chinese Journal of Radiological Medicine and Protection,2025,45(7):679-684 |
| Development of adjustable spatial resolution cone beam CT for small animals |
| Received:August 18, 2024 |
| DOI：10.3760/cma.j.cn112271-20240818-00309 |
| KeyWords:Adjustable spatial resolution Cone beam CT Field of view Small animal imaging |
| FundProject:山东省自然科学基金(ZR2022QH188) |
| Author Name | Affiliation | E-mail | | Li Yingxu | Department of Medical Equipment, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Xu Xilong | Shandong Maide Yinghua Technology Co., Ltd., Linyi 276111, China | | | Zhang Yanhai | Department of Medical Equipment, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Fu Xinlei | Shandong Maide Yinghua Technology Co., Ltd., Linyi 276111, China | | | Gao Feng | Department of Medical Equipment, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Cheng Yang | Department of Medical Equipment, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Lin Wei | Shandong Maide Yinghua Technology Co., Ltd., Linyi 276111, China | | | Chen Yu | Shandong Maide Yinghua Technology Co., Ltd., Linyi 276111, China | | | Li Chengqiang | Department of Medical Equipment, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Lu Jie | Department of Medical Equipment, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | llujie@163.com |
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| Abstract:: |
| Objective To design and develop a cone-beam CT imaging system for small animals with continuously adjustable spatial resolution. Methods The imaging system used an X-ray source with a focal spot size of 30 μm and a flat panel detector with a pixel size of 100 μm. On this premise, a "stepping-focusing-rotating" image acquisition mode was proposed, in which the "focusing" and "stepping" systems were sequentially embedded in the "rotating" system. In this acquisition mode, the X-ray source and flat panel detector were relatively stationary to form the "focusing" system. When the "stepping" system accurately transported the object to the scanning position, the "focusing" system could achieve adjustable spatial resolution by making linear motion around the object to be scanned according to different experimental requirements. Finally the "rotating" system achieve high-quality imaging. Results The variable spatial resolution of small animal CBCT ranges from 35.7 μm to 71.4 μm, and the FOV ranges from 39.6 mm to 108.0 mm. The conversion time for the limit spatial resolution is 19.125 s, which allowed accurate 3D reconstruction of normal mice at different resolutions with high reproducibility. Conclusions A cone-beam CT suitable for small animals has been developed, whose spatial resolution and FOV can be adjusted arbitrarily within a certain range, which can meet the different imaging requirements in rodent experiments. |
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