| Cao Ye,Shu Diyun,Xiao Yufeng,et al.In vivo measurement of radionuclides and radiation levels around patients after BNCT treatment[J].Chinese Journal of Radiological Medicine and Protection,2025,45(7):668-673 |
| In vivo measurement of radionuclides and radiation levels around patients after BNCT treatment |
| Received:August 19, 2024 |
| DOI：10.3760/cma.j.cn112271-20240819-00310 |
| KeyWords:Boron neutron capture therapy (BNCT) Radiation protection Dose Neutron activation |
| FundProject:厦门市医疗卫生指导性项目(3502Z20224ZD1101);国家自然科学基金(12261131621) |
| Author Name | Affiliation | E-mail | | Cao Ye | Xiamen Humanity Hospital, BNCT Center, Xiamen 361006, China
Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China | | | Shu Diyun | Neuboron Therapy System Ltd., Xiamen 361000, China | | | Xiao Yufeng | Xiamen Humanity Hospital, BNCT Center, Xiamen 361006, China | | | Lai Youqun | Xiamen Humanity Hospital, BNCT Center, Xiamen 361006, China | laiyouqun@haxm.com | | Cheng Jinsheng | Key Laboratory of Radiation Protection and Nuclear Emergency, National Institute for Radiological Protection, China CDC, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Zheng Senxing | Fujian Center for Prevention and Control of Occupational Diseases and Chemical Poisoning, Fuzhou 350000, China | | | Yuan Jilong | Key Laboratory of Radiation Protection and Nuclear Emergency, National Institute for Radiological Protection, China CDC, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | | Miu Xiaohua | Fujian Center for Prevention and Control of Occupational Diseases and Chemical Poisoning, Fuzhou 350000, China | | | Pan Jianji | Xiamen Humanity Hospital, BNCT Center, Xiamen 361006, China | | | Liu Yuanhao | Xiamen Humanity Hospital, BNCT Center, Xiamen 361006, China
Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
Neuboron Therapy System Ltd., Xiamen 361000, China
Neuboron Medtech Ltd., Nanjing 211112, China | |
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| Abstract:: |
| Objective To explore the in vitro radiation levels and in vivo neutron activation after patients receiving boron neutron capture therapy (BNCT). Methods Totally 29 BNCT treatments were performed for 21 patients with head and neck and brain cancer using the NeuPex accelerator-based boron neutron capture therapy (AB-BNCT) system in Xiamen Humanity Hospital from October, 2022 to April, 2024. The ambient dose equivalent rate around the patients was measured with an X/gamma dose rate survey meter. The gamma radiation dose rates were measured at 0, 0.5, 1.0, and 2.0 m from the irradiation position, at 0, 0.5, 1.0, and 2.0 m from the opposite side of the irradiation position, and at the navel and the affected knee, respectively. Meanwhile, a portable high-purity germanium gamma spectrometer was used to measure the spectrum of activated nuclides in the bodies of patients who had underwent the treatment, and the types of radionuclides generated by neutron activation during each BNCT treatment were analyzed. Results The radionuclides 24Na, 38Cl, and 49Ca were mainly produced in the bodies of patients treated with BNCT. 20 minutes after BNCT treatment, the ambient dose equivalent rate at a distance of 1.0 m from the irradiation position was lower than 2.5 μSv/h. Conclusions The dose delivered to the staff and family members by the patients undergoing BNCT is relatively low, and the resulting radiation risk is low. According to the ALARA principle, it is recommended that certain control actions be taken for patients having received BNCT treatment to minimize the exposure doses of both patients and staff as much as possible. |
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