| Song Honghu,Piao Zun,Huang Guomin,et al.Impacts of the radiosensitivity of cell lines on a microdosimetric kinetic model[J].Chinese Journal of Radiological Medicine and Protection,2025,45(5):416-422 |
| Impacts of the radiosensitivity of cell lines on a microdosimetric kinetic model |
| Received:August 08, 2024 |
| DOI：10.3760/cma.j.cn112271-20240808-00302 |
| KeyWords:Carbon-ion radiotherapy Cellular radiosensitivity Microdosimetric kinetic model (MKM) Relative biological effectiveness (RBE) |
| FundProject: |
| Author Name | Affiliation | E-mail | | Song Honghu | Sun Yat-sen University Cancer Center, Guangzhou 510060, China
United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co., Ltd, Guangzhou 510060, China | | | Piao Zun | Sun Yat-sen University Cancer Center, Guangzhou 510060, China | | | Huang Guomin | Sun Yat-sen University Cancer Center, Guangzhou 510060, China
United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co., Ltd, Guangzhou 510060, China | | | Shi Jian | United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co., Ltd, Guangzhou 510060, China | | | Chen Ming | Sun Yat-sen University Cancer Center, Guangzhou 510060, China
United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co., Ltd, Guangzhou 510060, China | | | Huang Xiaoyan | Sun Yat-sen University Cancer Center, Guangzhou 510060, China
United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co., Ltd, Guangzhou 510060, China | huangxiaoy@sysucc.org.cn |
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| Abstract:: |
| Objective To investigate the impacts of the radiosensitivity of cell lines on a microdosimetric kinetic model (MKM) used in carbon-ion radiotherapy. Methods The saturation-corrected specific energy (z1d*) of monoenergetic carbon ions was calculated using the Kiefer-Chatterjee (K-C) track structure model. Correction curve f(LET) was derived from experimental data on relative biological effectiveness (RBE) (RBEDSB-LET) defined based on the double-strand DNA break of the Chinese hamster ovary (CHO) and Fibroblast cell lines irradiated using carbon ions with varying linear energy transfer (LET) values. Then, based on the MKM, the D10-LET curves, as well as α and β databases, of the CHO and Fibroblast cell lines with varying radiosensitivity were determined. Results Compared to the clinically applied MKM, the predicted D10 after correction while accounting for cell line radiosensitivity agreed better with experimental D10 values of the CHO and Fibroblast cell lines. Specifically, compared to experimental values in the literature, the D10 values calculated in the study and determined using the MKM showed mean squared errors (MSEs) of 0.04 and 0.71, for the CHO cell line and 0.35 and 0.55, respectively, for the Fibroblast cell line. For monoenergetic carbon ions with varying LET values, the calculated α and β values generally increased with cellular radiosensitivity. Conclusions Incorporating cellular radiosensitivity into the MKM framework serves as a more specific method for RBE assessment while also providing a reference for advancing MKM applications and achieving the fine-scale calculations of RBE in carbon-ion radiotherapy. |
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