| Song Xuejiao,Li Meng,Shi Mei.Research advances in the prevention and treatment of sensorineural hearing loss following chemoradiotherapy for head and neck cancers[J].Chinese Journal of Radiological Medicine and Protection,2025,45(4):368-373 |
| Research advances in the prevention and treatment of sensorineural hearing loss following chemoradiotherapy for head and neck cancers |
| Received:October 01, 2024 |
| DOI：10.3760/cma.j.cn112271-20241001-00390 |
| KeyWords:Head and neck cancer (HNC) Radiotherapy Chemotherapy Sensorineural hearing loss (SNHL) |
| FundProject:国家自然科学基金项目(82272735) |
| Author Name | Affiliation | E-mail | | Song Xuejiao | Department of Radiation Oncology, First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China | | | Li Meng | Department of Biopharmaceutics, School of Pharmacy, Air Force Medical University, Xi'an, 710032, China | | | Shi Mei | Department of Radiation Oncology, First Affiliated Hospital of Air Force Medical University, Xi'an 710032, China | mshi82@fmmu.edu.cn |
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| Abstract:: |
| Sensorineural hearing loss (SNHL) is recognized as the most severe ototoxic complication following radiotherapy or chemoradiotherapy in patients with head and neck cancers (HNCs). It significantly impairs patients' quality of life due to the lack of effective drugs. Although advances in radiotherapy techniques have played a crucial role in improving patients' survival rates and protecting organs at risk, SNHL remains inevitable. This review presents the diagnosis, differential diagnosis, clinical manifestations, assessment criteria, pathogenesis, risk factors, and prophylactic/therapeutic strategies of SNHL, in order to provide novel insights for clinical diagnosis, treatment, and prevention. |
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