| Chen Guanyou,Chen Huifeng,Li Huixian,et al.A study on inflammatory indicators levels and influencing factors of middle-aged and elderly male residents around a uranium mine[J].Chinese Journal of Radiological Medicine and Protection,2025,45(4):325-333 |
| A study on inflammatory indicators levels and influencing factors of middle-aged and elderly male residents around a uranium mine |
| Received:September 03, 2024 |
| DOI：10.3760/cma.j.cn112271-20240903-00337 |
| KeyWords:Uranium mine Inflammatory cells Inflammatory factors Middle-aged and elderly residents |
| FundProject:广东省基础与应用基础研究基金(2019A1515011969,2022A1515012421,2023A1515010414) |
| Author Name | Affiliation | E-mail | | Chen Guanyou | Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China
School of Public Health, Sun Yat-sen University, Guangzhou 510080, China | | | Chen Huifeng | Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China | | | Li Huixian | Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China
School of Public Health, Sun Yat-sen University, Guangzhou 510080, China | | | Huang Weixu | Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China | | | Zou Jianming | Guangdong Province Hospital for Occupational Disease Prevention and Treatment, Guangzhou 510300, China | zjm990916@126.com |
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| Abstract:: |
| Objective To investigate the inflammatory indicator levels and influencing factors on middle-aged and elderly male residents at different residential distances from a uranium mine in Guangdong, so as to provide scientific data for the health risk assessment of the residents therein. Methods With stratified sampling method, two groups of the permanent middle-aged and elderly male residents were randomly sampled within < 10 km and 10-20 km of the uranium mine, along with the basic demographic characteristics and lifestyle information collected through face-to-face questionnaire survey. Both height and weight of the respondents were measured using standard method and their body mass indexes (BMI) were calculated. Through collection of the venous blood, the levels of a wide range of inflammatory indicators were measured, such as C-reactive protein (CRP), complement C3, complement C4, leukocytes, lymphocytes, neutrophils, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and others. Multiple linear regression was used to analyze the influencing factors on the levels of inflammation indicators. Results A total of 867 middle-aged and elderly male residents were included in this study, including one group of 431 residents within the 10-20 km at an average age of 51.54±5.37, and a second group of 436 residents within <10 km at an average age of 52.05±5.24. The result of multiple linear regression showed a positive correlation of the distance groups with complement C4 level (β=0.014, 95%CI:0.001-0.027) and lymphocyte number (β=0.086, 95%CI:0.003-0.168) (t=2.07, 2.04,P<0.05). The ages of middle-aged and elderly male residents around the uranium mine was positively correlated (t=2.50,P<0.05) with the levels of complement C4 (β=0.018, 95%CI:0.004-0.031), and negatively correlated (t=-3.25, -2.97,P<0.05) with the levels of TNF-α (β=-63.022, 95%CI:-101.114 to -24.929) and IL-6 (β=-14.694, 95%CI:-24.396 to -4.992). Smoking was positively correlated (t=4.29, 4.81, 3.19,P<0.05) with leukocytes number (β=0.630, 95%CI:0.341-0.918), lymphocytes number (β=0.226, 95%CI:0.134-0.319) and neutrophils number (β=0.372, 95%CI:0.143-0.601), and negatively correlated (t=-2.07, -1.98,P<0.05) with the levels of TNF-α (β=-43.551, 95%CI:-84.778 to -2.324) and IL-6 (β=-10.603, 95%CI:-21.103 to -0.102). BMI was positively correlated (t=8.60, 3.62, 3.18, 4.01, 2.10,P<0.05) with complement C3 level (β=0.108, 95%CI:0.084-0.133), complement C4 level (β=0.026, 95%CI:0.012-0.039), leukocytes number (β=0.433, 95%CI:0.166-0.699), lymphocyte number (β=0.175, 95%CI:0.089-0.261), and neutrophil number (β=0.226, 95%CI:0.014-0.438). Fruit consumption (β=0.017, 95%CI:0.001-0.034) was positively correlated with complement C4 levels (t=2.10,P<0.05). Conclusions This study showed no significant correlation between the inflammatory index levels of middle-aged and elderly male residents around the uranium mine and uranium mining. Age, smoking, BMI and fruit consumption were the influencing factors on the levels of inflammatory indicators of middle-aged and elderly male residents. |
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