| Cheng Xu,Chen Moli,Zhao Guoping,et al.Research advances in the role of gut microbiota in radiotherapy sensitivity and radiation-induced injury[J].Chinese Journal of Radiological Medicine and Protection,2025,45(3):243-248 |
| Research advances in the role of gut microbiota in radiotherapy sensitivity and radiation-induced injury |
| Received:April 21, 2024 |
| DOI：10.3760/cma.j.cn112271-20240421-00148 |
| KeyWords:Gut microbiome Radiotherapy Adverse effect Immune response |
| FundProject:国家自然科学基金(32171240);中国科学院合肥肿瘤医院优秀医学青年人才计划(YQJH2023004) |
| Author Name | Affiliation | E-mail | | Cheng Xu | Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230031, China
Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China | | | Chen Moli | Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230031, China
Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China | | | Zhao Guoping | High Magnetic Field Laboratory, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China | gpz@ipp.ac.cn | | Wang Hongzhi | Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230031, China
Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China | |
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| Abstract:: |
| Radiotherapy remains one of the primary therapeutic modalities for various cancers. However, individual heterogeneity exists in treatment outcomes and adverse reactions. In recent years, the interaction between the gut microbiota and radiotherapy has garnered increasing attention. The gut microbiota plays a crucial role in modulating host immune responses, maintaining intestinal barrier integrity, and participating in metabolic processes, thereby influencing both the efficacy and tolerance of radiotherapy. Modulating gut microbiota composition through probiotics, antibiotics, or dietary interventions may reduce the toxic side effects induced by radiotherapy, thereby enhancing therapeutic outcomes. Despite numerous challenges in mechanistic studies and clinical application, current research has shed light on cancer therapies. This review emphasizes the significant role of gut microbiota in radiotherapy, impacting treatment outcomes and patients’ tolerance and quality of life. Future research should further explore the links between microbiota regulation and optimization of radiotherapy outcomes, with the prospect of translating these strategies into clinical practice to provide more personalized treatment options for patients. |
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