| Dong Fangfen,Wu Bing,Wang Zhixin,et al.Impacts of the frequency of orthogonal image guided-verification on set-up error correction and PTV margins in postoperative radiotherapy for breast cancer[J].Chinese Journal of Radiological Medicine and Protection,2025,45(1):37-42 |
| Impacts of the frequency of orthogonal image guided-verification on set-up error correction and PTV margins in postoperative radiotherapy for breast cancer |
| Received:May 16, 2024 |
| DOI：10.3760/cma.j.cn112271-20240516-00180 |
| KeyWords:Breast cancer Image-guided frequency Set-up error Planning target volume margin |
| FundProject:福建省卫生健康青年科研课题(2022QNA018);福建医科大学启航基金项目资助(2022QH1029) |
| Author Name | Affiliation | E-mail | | Dong Fangfen | Department of Radiation Oncology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China
School of Medical Imaging, Fujian Medical University, Fuzhou 350122, China | | | Wu Bing | School of Medical Imaging, Fujian Medical University, Fuzhou 350122, China | | | Wang Zhixin | School of Medical Imaging, Fujian Medical University, Fuzhou 350122, China | | | Li Jiaming | School of Medical Imaging, Fujian Medical University, Fuzhou 350122, China | | | Huang Miaoyun | Department of Radiation Oncology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China
School of Medical Imaging, Fujian Medical University, Fuzhou 350122, China | | | Yang Yong | Department of Radiation Oncology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China
School of Medical Imaging, Fujian Medical University, Fuzhou 350122, China | | | Xu Benhua | Department of Radiation Oncology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China
School of Medical Imaging, Fujian Medical University, Fuzhou 350122, China | | | Li Xiaobo | Department of Radiation Oncology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China
School of Medical Imaging, Fujian Medical University, Fuzhou 350122, China
Department of Engineering Physics, Tsinghua University, Beijing 100084, China
Department of Radiation Oncology, Zhangpu County Hospital, Zhangpu 363299, China | lixiaobo2004@126.com |
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| Abstract:: |
| Objective To explore the impacts of different frequencies of orthogonal image-guided verification on set-up error correction and the reference values of planning target volume (PTV) margins in postoperative radiotherapy for breast cancer, in order to provide recommendations of the verification frequency in clinical practice. Methods A total of 80 breast cancer patients who received postoperative intensity-modulated radiotherapy for breast cancer at the Affiliated Union Hospital of Fujian Medical University from January 2021 to January 2022 were enrolled. Orthogonal image-guided verification was conducted before each radiation treatment to determine initial and residual set-up errors. The error data were statistically analyzed by categorizing patients into groups A, B, C, D, E, and F, based on assumed verification frequencies (daily, every 2, 3, 4, and 5 d, and no correction). The magnitude, distribution, and differences of set-up errors of various groups were analyzed, and the PTV margins were calculated using a reference formula. Results The collected initial set-up errors of the 80 patients were (3.49±3.43), (2.87±2.88), and (2.75±2.35) mm, in x, y, and z directions, respectively. The residual set-up errors decreased gradually with increasing verification frequency. In the case of daily image-guided verification, the residual set-up errors in x, y, and z directions decreased to (1.63±0.90), (1.63±0.93), and (1.55±0.90) mm, respectively. The reference values of PTV margins calculated under different verification frequencies decreased with an increase in the verification frequency. Under daily verification, the reference values of PTV margins calculated based on set-up errors decreased from initial 6.60, 6.29, and 4.22 mm (without correction) to 1.27, 1.37, and 1.28 mm, respectively. Differences in the reference values under verification frequencies every 3, 4, and 5 d were less than 0.81 mm. Conclusions Daily image-guided verification (including correction) can effectively reduce set-up errors in image-guided radiotherapy for breast cancer. The set-up errors differ under varying verification frequencies, with a higher frequency corresponding to better correction effects and smaller PTV margins required. |
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