| Wu Ailin,Yan Lin,Wu Xinglei,et al.Study on AlignRT guided set-up of breast-conserving radiotherapy and the impact of patients' thoracic characteristic parameters[J].Chinese Journal of Radiological Medicine and Protection,2025,45(1):24-30 |
| Study on AlignRT guided set-up of breast-conserving radiotherapy and the impact of patients' thoracic characteristic parameters |
| Received:April 24, 2024 |
| DOI：10.3760/cma.j.cn112271-20240424-00153 |
| KeyWords:Breast cancer Breast-conserving radiotherapy Surface-guided radiation therapy Set-up error Thoracic characteristic parameters |
| FundProject:国家自然科学基金(11805198);中国科学技术大学附属第一医院院内基金(2022YJQN015) |
| Author Name | Affiliation | E-mail | | Wu Ailin | Department of Radiation Oncology, First Affiliated Hospital of USTC, Division of Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China
Department of Radiation Oncology, Anhui Provincial Cancer Hospital, Hefei 230031, China | | | Yan Lin | Department of Radiation Oncology, First Affiliated Hospital of USTC, Division of Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China
Department of Radiation Oncology, Anhui Provincial Cancer Hospital, Hefei 230031, China | | | Wu Xinglei | Department of Radiation Oncology, First Affiliated Hospital of USTC, Division of Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China
Department of Radiation Oncology, Anhui Provincial Cancer Hospital, Hefei 230031, China | | | Zhang Peng | Department of Radiation Oncology, First Affiliated Hospital of USTC, Division of Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China
Department of Radiation Oncology, Anhui Provincial Cancer Hospital, Hefei 230031, China | | | Cheng Jingjing | Department of Radiation Oncology, First Affiliated Hospital of USTC, Division of Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China
Department of Radiation Oncology, Anhui Provincial Cancer Hospital, Hefei 230031, China | | | Zang Chunbao | Department of Radiation Oncology, First Affiliated Hospital of USTC, Division of Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China
Department of Radiation Oncology, Anhui Provincial Cancer Hospital, Hefei 230031, China | | | Zhang Hongbo | Department of Radiation Oncology, First Affiliated Hospital of USTC, Division of Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China
Department of Radiation Oncology, Anhui Provincial Cancer Hospital, Hefei 230031, China | | | Wu Aidong | Department of Radiation Oncology, First Affiliated Hospital of USTC, Division of Sciences and Medicine, University of Science and Technology of China, Hefei 230031, China
Department of Radiation Oncology, Anhui Provincial Cancer Hospital, Hefei 230031, China | flkaidongwu@163.com |
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| Abstract:: |
| Objective To compare the impact of the AlignRT-based optical guidance method with the traditional marker line method on the accuracy of positioning, and explore the effect of patient's different thoracic characteristic parameters on the precision of optical guidance positioning. Methods A total of sixty breast cancer patients who received post breast-conserving radiotherapy at Anhui Cancer Hospital from July 2022 to September 2023 were retrospectively selected. Then these patients were equally divided into traditional cross hairs set-up (marker line group) and surface-guided set-up (SGRT group). The cone-beam CT scanning results were used as the gold standard, the three-dimensional set-up errors and the CTV-PTV target area external radiotherapy boundaries of two groups were studied comparatively. Multiple patient's thoracic characteristic parameters were defined and the correction between each parameter and set-up error of SGRT was analyzed. Results The mean value of three-dimensional set-up errors in the SGRT group and the marker line group was within 0.2 cm and 0.5 cm, respectively. The differences in three-dimensional set-up errors and total displacements between two groups were statistically significant (z = -2.93, -3.21, -2.59, -4.76, P < 0.05). The SGRT group reduced the CTV-PTV boundary from 0.5cm of conventional marker line group to 0.3 cm. The thoracic aspect ratio H/W, the affected side pinch angle α1, and the healthy side pinch angle α2 were positively correlated with the x-direction posing error (r = 0.49, 0.59, 0.71, P<0.05); whereas, the affected side and the healthy side mammary gland heights D1 and D2 were negatively correlated with the z-direction posing error (r = -0.46, -0.49, P<0.05). Conclusions For breast-conserving postoperative radiotherapy patients, SGRT can obtain a more accurate radiotherapy set-up than the traditional marker line method, and can effectively reduce the target area externally expanded range. Meanwhile, the monitoring accuracy of SGRT is affected by the patient's thoracic characteristic parameters, and clinical attention should be paid to breast-conserving radiotherapy patients with thick body shape, narrow body width, and small breast glands. |
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