| Yang Yiyan,Wang Weidong.p53 dynamics: from determining cell fate to inflammation and immune regulation[J].Chinese Journal of Radiological Medicine and Protection,2024,44(12):1090-1094 |
| p53 dynamics: from determining cell fate to inflammation and immune regulation |
| Received:April 08, 2024 |
| DOI：10.3760/cma.j.cn112271-20240408-00121 |
| KeyWords:p53 Dynamics Cell fate Inflammation Immunity |
| FundProject:四川省自然科学基金重点项目(2022NSFSC0051) |
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| Abstract:: |
| Since p53 was discovered in 1979, the understanding of its roles and functions has continuously changed. Initially, p53 was known as a cancer gene and tumor suppressor gene, with a 50% mutation rate in tumors. Then, p53 was found to be involved in cell cycle regulation, genomic stability, apoptosis, and cell aging. More recently, it has been discovered that p53 plays a role in inflammation and immune regulation. As the information processing center of cellular stress responses, p53 dynamics not only encode the types and intensity of stress but also regulate multiple downstream genes, determining the fate of cells and closely related to the radiosensitivity of tissues. The primary mechanism behind p53 dynamics is to initiate multiple feedback loops represented by MDM2. Specifically, p53 is not only directly involved in innate immune responses such as cGAS-TING and adaptive immune responses dominated by T and B cells but also associated with various inflammatory responses. Its mutants provide new antigens for tumor immunity. Although targeted therapy against p53 in cancer has not yet been clinically successful, the new strategies for immune regulation using p53 may provide a new chance of cancer therapy for human beings. |
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