| Liu Junyi,Cheng Bo,Peng Zhao,et al.Exploring the feasibility of GPU-based fast Monte Carlo software ARCHER-NM in calculating individualized doses of beta radiopharmaceutical therapy[J].Chinese Journal of Radiological Medicine and Protection,2024,44(10):871-878 |
| Exploring the feasibility of GPU-based fast Monte Carlo software ARCHER-NM in calculating individualized doses of beta radiopharmaceutical therapy |
| Received:December 05, 2023 |
| DOI：10.3760/cma.j.cn112271-20231205-00200 |
| KeyWords:Monte Carlo Radiopharmaceutical therapy (RPT) Calculation of individualized dose |
| FundProject: |
| Author Name | Affiliation | | Liu Junyi | University of Science and Technology of China, School of Nuclear Science and Technology, Hefei 230026, China | | Cheng Bo | University of Science and Technology of China, School of Nuclear Science and Technology, Hefei 230026, China | | Peng Zhao | Xiangya Hospital Central South University, Department of Oncology, Changsha 410008, China | | Qi Miao | University of Science and Technology of China, School of Nuclear Science and Technology, Hefei 230026, China | | Pei Xi | Anhui Wisdom Technology Co., Ltd, Hefei 230026, China | | Xu Xie | University of Science and Technology of China, School of Nuclear Science and Technology, Hefei 230026, China
First Affiliated Hospital of University of Science and Technology of China, Department of Radiation Oncology, Hefei 230026, China |
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| Abstract:: |
| Objective To verify the feasibility and advantages of ARCHER-NM, a GPU-based fast Monte Carlo (MC) dose calculation engine, in calculating individualized doses of radiopharmaceutical therapy (RPT) through simulation experiments. Methods The calculation reliability and efficiency of ARCHER-NM were verified by comparing its result with those of the MC software GATE in the water phantom experiments of radionuclide point sources and the dose calculations for RPT-treated patients. In the water phantom experiments, the generality of ARCHER-NM on different radionuclides was verified using common radionuclides like 67Cu, 89Sr, 90Y, 131I, 177Lu, and 188Re. The calculations of individualized doses for RPT-treated patients were tested based on the data of two patients from the University of Michigan's public dataset for 177Lu-DOTATATE-treated cases. Gamma passing rates, dose volume histograms (DVHs), and average organ doses were employed to assess the consistency of ARCHER-NM and GATE in patients' dose calculation result. The computing time was statistically analyzed to assess the efficiency of MC calculations. Results In the water phantom experiments for all radionuclides, the relative differences of average doses between ARCHER-NM and GATE ranged from -1.63% to 2.29%, with an average absolute difference of 1.15%, suggesting high consistency. As indicated by the dose result of the two patients, the average doses for all organs between ARCHER-NM and GATE exhibited percentage errors of below 4%. The gamma passing rates for the two patients were 98.8% and 98.6%, respectively, under the 2 mm/1% standard within the 3% maximum dose isodose line. The simulation of 5×109decay required 90 s for ARCHER-NM on a personal host configured with a 24 GB Nvidia Titan RTX, whereas GATE took over 9 h on a 112-thread server for the same simulation. Conclusions The water phantom experiments substantiate the accuracy and generality of ARCHER-NM for dose calculations. Based on the organ dose calculations of 177Lu-DOTATATE-treated patients, ARCHER-NM proves accurate and quick in calculating the individualized internal doses for RPT-treated patients. Therefore, ARCHER-NM plays a positive role in the dose planning of subsequent treatment and the protection of organs at risk including kidneys. |
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