Liu Hongming,Qiu Rui,Li Junli.The progress in dosimetric evaluation methods for 90Y microspheres radioembolization[J].Chinese Journal of Radiological Medicine and Protection,2024,44(9):809-818
The progress in dosimetric evaluation methods for 90Y microspheres radioembolization
Received:April 18, 2024  
DOI:10.3760/cma.j.cn112271-20240418-00142
KeyWords:90Y microsphere  Dosimetry evaluation methods  Radioembolization
FundProject:国家自然科学基金(12375312);国家重点研发计划(2021YFF0603600)
Author NameAffiliation
Liu Hongming Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China 
Qiu Rui Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China 
Li Junli Key Laboratory of Particle & Radiation Imaging, Ministry of Education, Department of Engineering Physics, Tsinghua University, Beijing 100084, China 
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Abstract::
      90Y microspheres radioembolization therapy is an emerging interventional technique used for the treatment and palliative care of intermediate and advanced liver cancer, which was registered by National Medical Products Administration for imported drugs in 2022. In order to improve the tumor response rate and reduce toxic effects, the dose assessment for the tumor and healthy tissues is implemented throughout treatment. The efficiency and accuracy of estimation method are the keys to improving the therapeutic effect. This article investigated and summarized six evaluation method and their latest progress, discussed the unique advantages and applicable scenarios of each methods, and explored the possible challenges faced in clinical applications. This study would support the development and standardization of dose prediction and evaluation in radioembolization with 90Y microspheres.
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