| Pan Yongxiang,Ding Lixin,Wang Feng,et al.Measurement of external radiation levels around patients treated with 177Lu-DOTA-TATE and preliminary estimation of doses to the surrounding personnel[J].Chinese Journal of Radiological Medicine and Protection,2024,44(9):783-788 |
| Measurement of external radiation levels around patients treated with 177Lu-DOTA-TATE and preliminary estimation of doses to the surrounding personnel |
| Received:July 25, 2024 |
| DOI：10.3760/cma.j.cn112271-20240725-00278 |
| KeyWords:177Lu-DOTA-TATE Neuroendocrine tumors External irradiation Radiation dose |
| FundProject:国家自然科学基金(82171980);海淀区卫生健康发展科研培育计划(HP2023-32-503004) |
| Author Name | Affiliation | E-mail | | Pan Yongxiang | Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing 100142, China | | | Ding Lixin | Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing 100142, China | | | Wang Feng | Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing 100142, China | windtigerwf@163.com | | Yang Zhi | Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals (National Medical Products Administration), Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Beijing 100142, China | |
|
| Hits: 2586 |
| Download times: 842 |
| Abstract:: |
| Objective To investigate the decay law of 177Lu-DOTA-TATE in the treatment of neuroendocrine tumors in patients with external radiation and the radiation dose to the surrounding persons. Methods The radiation dose rate from patients to the surrounding environment after 177Lu-DOTA-TATE treatment was measured using a handheld radiation dosimeter at different times. The decay law of the radiation dose rate with time and distance was analyzed, and the radiation levels at different distances from the patients and the radiation dose of the patients to the surrounding persons were estimated. Results The external radiation dose rate from the patients decayed exponentially with time rapidly in the early stage and gradually slowly in the later stage. The effective half-life was (1.41±0.25) h (0.9-1.8) h in the rapid decay stage and (40.18±6.0) h (32.7-54.73 h) in the slower decay stage. At 0 h after injection, the normalized mean radiation dose rates at 0.25, 0.5, 1, 2, and 3 m away from the patient were 41.7±6.3, 20.0±3.0, 7.2±3.8, 3.4±0.9, and 1.9±0.4 μSv·h-1·GBq-1, respectively. The radiation doses to doctors, nurses, physicists, and positioning technicians were 2.0, 10.24, 1.08, and 4.05 μSv/patient, respectively. Conclusions The external radiation dose rate from patients receiving 177Lu-DOTA-TATE treatment rapidly decreases over time and distance. The radiation levels that patients may cause to the surrounding workers are within the allowable range of national standards. After discharge, patients should reduce close and long-term contact with the surrounding persons. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
