| Chen Wei,Du Fenglei,Zuo Guoping,et al.Distribution of brain metastases from adenocarcinoma and non-adenocarcinoma among non-small cell lung cancer[J].Chinese Journal of Radiological Medicine and Protection,2024,44(9):758-763 |
| Distribution of brain metastases from adenocarcinoma and non-adenocarcinoma among non-small cell lung cancer |
| Received:January 22, 2024 |
| DOI：10.3760/cma.j.cn112271-20240122-00028 |
| KeyWords:Non-small cell lung cancer (NSCLC) Adenocarcinoma Non-adenocarcinoma Brain metastasis Spatial distribution |
| FundProject:浙江省医药卫生项目(2021PY040);福建省科技计划项目(2023Y0059);福建省卫健委计划课题(2021CXB013) |
| Author Name | Affiliation | E-mail | | Chen Wei | School of Nuclear Science and Technology, University of South China, Hengyang 421001, China | | | Du Fenglei | Radiation Physics Department of Cancer Hospital Affiliated to University of Chinese Academy of Sciences Zhejiang Cancer Hospital, Hangzhou 310022, China | | | Zuo Guoping | School of Nuclear Science and Technology, University of South China, Hengyang 421001, China | zuogp@usc.edu.cn | | Chen Kaiqiang | Radiotherapy Center of Fujian Cancer Hospital, Fuzhou 350014, China | | | Shan Guoping | Radiation Physics Department of Cancer Hospital Affiliated to University of Chinese Academy of Sciences Zhejiang Cancer Hospital, Hangzhou 310022, China | |
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| Abstract:: |
| Objective To explore the differences in the spatial distributions of brain metastases (BMs) from adenocarcinoma and non-adenocarcinoma among non-small cell lung cancer (NSCLS), aiming to provide a reference for developing optimal treatment protocols. Methods A retrospective analysis was performed on data from 283 patients with NSCLC who underwent radiotherapy at the Zhejiang Cancer Hospital from January 2020 to July 2023. These patients included 191 adenocarcinoma cases with an average age of 62.04 years and 92 non-adenocarcinoma cases with an average age of 63.85 years. CT images with detected BMs of these patients were synchronously deformed and registered into a standard brain template to determine the distribution of BMs in the template. The Dice coefficient was employed to analyze the similarity in the distribution of BMs from adenocarcinoma and non-adenocarcinoma, and two-sample t-test was performed respectively using SPM and Dpabi software to ensure the consistency of the result. For brain regions with the number of BMs greater than or equal to 4, the voxels with a size 2 mm×2 mm×2 mm were counted. Results Non-adenocarcinoma tended to invade the posterior lobe of the cerebellum, precuneus, anterior lobe of the cerebellum, cuneus, middle occipital gyrus, and middle temporal gyrus, with corresponding voxel counts of 2 577, 2 291, 1 947, 1 550, 1 200, and 600, respectively. In contrast, adenocarcinoma was more commonly metastasized to the inferior parietal lobule, posterior lobe of the cerebellum, central frontal gyrus, precentral gyrus, middle temporal gyrus, and precuneus, with the corresponding voxel counts of 211, 201, 194, 186, 137, and 84, respectively. Conclusion Brain metastases exhibit different distributions between adenocarcinoma and non-adenocarcinoma, and both subtypes prefer to invade specific brain regions. |
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