| Wang Ting,Yu Sutong,Li Jie,et al.Research progress on the ionizing radiation-induced mutational signatures[J].Chinese Journal of Radiological Medicine and Protection,2024,44(7):628-632 |
| Research progress on the ionizing radiation-induced mutational signatures |
| Received:November 23, 2023 |
| DOI：10.3760/cma.j.cn112271-20231123-00185 |
| KeyWords:Ionizing radiation Mutation Mutational signature Tumor |
| FundProject:国家自然科学基金(82273583) |
| Author Name | Affiliation | E-mail | | Wang Ting | School of Radiation Medicine and Protection of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China | | | Yu Sutong | School of Radiation Medicine and Protection of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China | | | Li Jie | School of Radiation Medicine and Protection of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China | | | Guo Yihan | School of Radiation Medicine and Protection of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China | | | Yu Jiahua | School of Radiation Medicine and Protection of Soochow University, State Key Laboratory of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou 215123, China | yujiahua@suda.edu.cn |
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| Abstract:: |
| In the past decade, high-throughput sequencing technologies have generated a massive amount of genomic mutation data. The interpretation of mutation data from tumor samples has revealed mutational features highly associated with carcinogenic factors, which are referred to as mutational signatures. These mutational signatures enable the assessment of the contribution rates of various carcinogenic factors during the multi-stage development of tumors. Ionizing radiation-induced gene mutations constitute the molecular basis for its carcinogenic effects. Clarifying the patterns of mutational signatures induced by ionizing radiation is of great importance for a profound understanding of stochastic effects. This review presents the research history and analytical method of mutational signatures as well as a comprehensive summary of the current status of research on mutational signatures induced by ionizing radiation. The future development of this field is also discussed. |
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