| Zhao Jing,Wang Huijuan,Ma Xiaoguo,et al.Therapeutic effects of Yufu ointment for acute radiation-induced skin injury[J].Chinese Journal of Radiological Medicine and Protection,2024,44(7):594-600 |
| Therapeutic effects of Yufu ointment for acute radiation-induced skin injury |
| Received:February 26, 2024 |
| DOI：10.3760/cma.j.cn112271-20240226-00071 |
| KeyWords:Yufu ointment Radiation-induced skin injury Pain Itching Burning |
| FundProject:河北省中医药管理局科研计划项目(2020190) |
| Author Name | Affiliation | E-mail | | Zhao Jing | Department of Radiotherapy, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Wang Huijuan | Department of Radiotherapy, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Ma Xiaoguo | Department of Radiotherapy, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Huang Xiaoting | Department of Radiotherapy, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Zhao Xiaochun | Department of Radiotherapy, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Li Pei | Department of Radiotherapy, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Wang Ye | Department of Nursing, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Jing Shaowu | Department of Radiotherapy, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Liang Junli | Department of Nursing, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | Wang Jun | Department of Radiotherapy, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China | wangjun0818@hebmu.edu.cn |
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| Abstract:: |
| Objective To evaluate the therapeutic effects of Yufu ointment for acute radiation-induced skin injury. Methods We enrolled a total of 104 patients with malignant tumors who developed acute skin injury of grade 2-3 during or after the first course of radiotherapy from June 2019 to February 2023. The observation group (n = 53) and control group (n = 51) received external application of Yufu ointment and Shirun Shaoshang ointment, respectively. We recorded the changes in the grade of skin injury and associated symptoms (such as pain, itching, and burning sensation) and healing speed and time for the two groups. Results A total of 102 patients completed the study, with 53 cases in the observation group and 49 cases in the control group. The incidence rate of moisture skin lesions in the observation group was significantly lower than that in the control group (62.26% vs. 83.67%, P<0.05). The healing speed of moisture skin ulcerations was significantly faster in the observation group than in the control group (1.67 cm2/d vs. 0.55 cm2/d, P<0.05). The observation group had a significantly shorter time to skin injury healing than the control group (10.40 d vs. 14.41 d, P<0.05), significantly different for skin injury of grade 2 (10.21 d vs. 17.57 d, P<0.05) but not for skin injury of grades 2.5 and 3 (P>0.05). Regarding clinical symptoms, both groups experienced significant reductions in pain and burning sensation scores after treatment (P<0.05); the grade of itching was significantly decreased for the observation group (P<0.05), but had no significant change for the control group after treatment (P>0.05). Conclusions Yufu ointment can significantly alleviate secondary damage for patients with acute radiation-induced skin injury, by accelerating the healing process and relieving symptoms such as pain, itching, and burning sensation with good tolerability, which deserves further promotion. |
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