| Wang Qingxin,Wang Zhongqiu,Wang Wei,et al.Advances in research on the role and mechanism of ferroptosis in radiation-induced injury[J].Chinese Journal of Radiological Medicine and Protection,2024,44(6):537-542 |
| Advances in research on the role and mechanism of ferroptosis in radiation-induced injury |
| Received:August 14, 2023 |
| DOI：10.3760/cma.j.cn112271-20230814-00045 |
| KeyWords:Radiotherapy Radiation-induced injury Ferroptosis |
| FundProject:国家自然科学基金(82272734);天津市医学重点学科(专科)建设项目(TJYXZDXK-009A) |
| Author Name | Affiliation | E-mail | | Wang Qingxin | Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China | | | Wang Zhongqiu | Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China | | | Wang Wei | Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China | | | Wang Peiguo | Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China | wpg2017@163.com |
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| Abstract:: |
| Radiotherapy plays an important role in the comprehensive treatment of malignant tumors. Radiation-induced injury (RII) of normal tissue in tumor patients receiving radiotherapy, to varying degrees, is the most common adverse reaction of radiotherapy and an important factor influencing the course of radiotherapy. However, there is a lack of efficient prevention and treatment measures for RII. Ferroptosis, a novel type of cell death, has been reported several times to be closely associated with normal tissue damage induced by radiotherapy. This paper reviews the advances in research on ferroptosis, as well as its mechanism and association with RII. |
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