| Wang Jiahao,Xie Hongling,Zhao Yadong,et al.Optical surface monitoring-based real-time 3D in vivo dose verification for patients with left breast cancer undergoing deep inspiration breath-hold radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2024,44(6):517-522 |
| Optical surface monitoring-based real-time 3D in vivo dose verification for patients with left breast cancer undergoing deep inspiration breath-hold radiotherapy |
| Received:January 09, 2024 |
| DOI：10.3760/cma.j.cn112271-20240109-00011 |
| KeyWords:Left breast cancer Deep inspiration breath-hold surface guided radiation therapy 3D in vivo dose verification γ pass rate |
| FundProject:浙江省基础公益研究计划(ZCLTGY24H1602) |
| Author Name | Affiliation | E-mail | | Wang Jiahao | Department of Radiation Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China | | | Xie Hongling | Department of Radiation Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China | | | Zhao Yadong | Department of Radiation Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China | | | Zhou Pengfei | Department of Radiation Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China | | | Li Hui | Department of Radiation Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China | | | Tang Qiu | Department of Radiation Oncology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310000, China | qiutang@zju.edu.cn |
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| Abstract:: |
| Objective To perform optical surface monitoring-based three-dimensional (3D) in vivo dose verification for patients with left breast cancer undergoing deep inspiration breath-hold surface-guided radiation therapy (DIBH-SGRT) and to investigate the dosimetric differences in the target volumes and related factors affecting γ pass rates. Methods Totally 20 patients with left breast cancer who received DIBH-SGRT at the Department of Radiation Oncology, Women's Hospital, School of Medicine, Zhejiang University were selected. The optical surface monitoring-based intrafractional displacement deviations of the patients during DIBH were recorded. Meanwhile, electronic portal imaging device (EPID)-based in vivo dosimetry (EIVD) verification was performed for patients during the DIBH-SGRT, and γ pass rates were measured with the criteria of 2 mm/2%, 3 mm/3%, and 3 mm/5%. The dosimetric differences between planning target volumes (PTVs) and organs at risk (OARs) were analyzed based on dose-volume histograms (DVHs). Furthermore, Pearson correlation analysis was employed to determine the correlation of three γ pass rates with dosimetric differences and displacement deviations. Results The average pass rates with the criteria of 2 mm/2%, 3 mm/3%, and 3 mm/5% were determined at 73. 43%, 86. 00%, and 92. 96%, respectively, and the average deviations between EIVD measured doses and planned doses in PTV_TB and PTV Dmean were proved to be 0.23% and 0.59%, respectively (P＞0. 05). Pearson analysis revealed that the γ pass rates exhibited a weak correlation with dosimetric differences in PTVs(R＜0.7) but strong correlations with intrafractional displacement deviations in Lat and Vert directions during DIBH (P＞0. 7). Conclusions EIVD verification can ensure the high accuracy of dose delivery in PTVs during DIBH-SGRT for left breast cancer. Additionally, the EIVD verification system has the potential to detect displacement deviations during breath holding. |
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