| Deng Jiarong,Zhang Wencheng,Shen Liping,et al.Role and research progress of snoRNAs in ionizing radiation-induced DNA damage[J].Chinese Journal of Radiological Medicine and Protection,2024,44(5):450-455 |
| Role and research progress of snoRNAs in ionizing radiation-induced DNA damage |
| Received:October 09, 2023 |
| DOI：10.3760/cma.j.cn112271-20231009-00111 |
| KeyWords:Small nucleolus RNA Ionizing radiation DNA damage response |
| FundProject:国家自然科学基金面上项目(32071240) |
| Author Name | Affiliation | E-mail | | Deng Jiarong | Graduate Collaborative Training Base of Academy of Military Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China
Department of Radiobiology Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | Zhang Wencheng | Department of Radiobiology Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | Shen Liping | Department of Radiobiology Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | | | Wang Zhidong | Graduate Collaborative Training Base of Academy of Military Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China
Department of Radiobiology Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China | wangzhidong1977@126.com |
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| Abstract:: |
| Small nucleolar RNAs (snoRNAs), a type of non-coding RNAs ubiquitous in eukaryotes, can be categorized into two types based on structural characteristics: box C/D snoRNAs and box H/ACA snoRNAs, which mediate the RNA modification of 2'-O-methylation and pseudouridylation, respectively. Recent studies have found that snoRNAs also affect the alternative splicing of mRNA precursors (pre-mRNA), mediate gene silencing by generating miRNA, and interact with proteins to regulate their functional activity. The process of DNA damage and repair always serves as a pivotal biological basis in research on the biological effects of ionizing radiation. Currently, there are rather limited studies on the role of snoRNAs in ionizing radiation-induced DNA damage. Thus, this paper reviews the biological functions of snoRNAs and their potential role in the regulatory repair of ionizing radiation-induced DNA damage, with a view to providing new ideas for exploring the function and mechanism of snoRNAs. |
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