| Liu Jia,Wang Lan,Guo Chunhui,et al.Preliminary clinical observations of low-dose radiotherapy for eight cases of severe/critical COVID-19[J].Chinese Journal of Radiological Medicine and Protection,2024,44(5):374-378 |
| Preliminary clinical observations of low-dose radiotherapy for eight cases of severe/critical COVID-19 |
| Received:August 10, 2023 |
| DOI：10.3760/cma.j.cn112271-20230810-00039 |
| KeyWords:COVID-19 Low-dose radiotherapy Pneumonia |
| FundProject:江苏省卫生健康委员会重点科研项目(ZD2021053);江阴市科技局社会发展科技示范项目(JY0603A021014210005PB);国家自然科学基金青年项目(82000012);无锡市卫生健康委中青年拔尖人才资助计划(BJ2023101);放射医学与辐防护国家重点实验室科研创新项目(GZC00402);无锡市卫生健康委员会青年科研项目(Q202333) 临床试验注册: 中国临床试验注册中心,ChiCTR2300070643 |
| Author Name | Affiliation | E-mail | | Liu Jia | Department of Radiotherapy, Jiangyin Hospital Affiliated to Nantong University, Jiangyin 214400, China | | | Wang Lan | Department of Respiratory, Jiangyin Hospital Affiliated to Nantong University, Jiangyin 214400, China | | | Guo Chunhui | Department of Infectious Diseases, Jiangyin Hospital Affiliated to Nantong University, Jiangyin 214400, China | | | Jiao Yang | State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou 215123, China | | | Sun Liang | State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou 215123, China | | | Xia Linyun | Department of Radiotherapy, Jiangyin Hospital Affiliated to Nantong University, Jiangyin 214400, China | | | Qin Jianjun | Department of Radiotherapy, Jiangyin Hospital Affiliated to Nantong University, Jiangyin 214400, China | | | Ju Min | Department of Radiotherapy, Jiangyin Hospital Affiliated to Nantong University, Jiangyin 214400, China | | | Cai Yiling | Department of Radiotherapy, Jiangyin Hospital Affiliated to Nantong University, Jiangyin 214400, China | | | Wang Jian | Department of Radiotherapy, Jiangyin Hospital Affiliated to Nantong University, Jiangyin 214400, China | 1627879372@qq.com |
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| Abstract:: |
| Objective To investigate the efficacy and adverse reactions of whole-lung low-dose radiotherapy (LDRT) in patients with severe/critical coronavirus disease 2019 (COVID-19). Methods Eight patients with severe/critical COVID-19 treated in the Jiangyin Hospital Affiliated to Nantong University from January to June 2023 who were treated with whole-lung LDRT after deteriorating or failing to improve post-medical treatment were enrolled in this single-arm phase I clinical trial. They received anterior-posterior penetrating radiation in a supine or prone position, with a total dose range from 0.5 to 1.5 Gy and a dose weight ratio of 1∶1. The oxygenation status, inflammatory markers, and imaging changes before and after radiotherapy were analyzed, and patients were followed up for acute radiation-induced adverse reactions. Results One week after LDRT, the SaO2/FiO2 or PaO2/FiO2 indices increased in seven patients (87.5%), inflammatory markers such as C-reactive protein (CRP) and interleukin-6 (IL-6) decreased in seven patients (87.5%), and chest CT/chest radiographs revealed a significant reduction in the extent of pneumonia involvement in 5 patients (62.5%). No evident acute radiation-related adverse reactions were observed. Conclusions Whole-lung LDRT with a dose range from 0.5 to 1.5 Gy can reduce inflammatory markers, improve clinical symptoms, and promote inflammatory absorption in patients with severe/critical COVID-19 who responded poorly to medical treatment while not inducing acute adverse reactions. |
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