| Zhang Yi,You Shihu,Luo Yuanqiang,et al.Monte Carlo simulation-based analysis of cell damage by 9C-ion decay products[J].Chinese Journal of Radiological Medicine and Protection,2024,44(5):361-366 |
| Monte Carlo simulation-based analysis of cell damage by 9C-ion decay products |
| Received:August 17, 2023 |
| DOI：10.3760/cma.j.cn112271-20230817-00050 |
| KeyWords:9C-ion Delayed particle Monte-Carlo simulation Cell surviving fraction |
| FundProject:贵州省抗癌协会科技计划项目([2023]15) |
| Author Name | Affiliation | E-mail | | Zhang Yi | Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550024, China
School of Nuclear Science and Technology, Lanzhou University, Lanzhou 730000, China | | | You Shihu | Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550024, China
Department of Radiophysics and Technology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550004, China | | | Luo Yuanqiang | Department of Radiophysics and Technology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550004, China | | | Wang Zhiyong | Department of Radiophysics and Technology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550004, China | | | Xu Congfeng | Department of Radiophysics and Technology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550004, China | | | Jin Haijie | Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550024, China
Department of Radiophysics and Technology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550004, China | | | Zhang Haojia | Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550024, China
Department of Radiophysics and Technology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550004, China | | | Hong Wei | Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550024, China
Department of Radiophysics and Technology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550004, China | | | Gan Jiaying | Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550024, China
Department of Radiophysics and Technology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550004, China | | | Hu Yinxiang | Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550024, China
Department of Radiophysics and Technology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550004, China
School of Clinical Medicine, Guizhou Medical University, Guiyang 550025, China | hyx_wengan@163.com |
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| Abstract:: |
| Objective To explore the radiological damage to cells induced by the delayed particles of 9C-ions for heavy ion therapy, as well as the microdosimetric distribution and biological effects of these particles on a single model of V79 Chinese hamster lung cells. Methods The Monte Carlo program was employed to simulate the endonuclear absorbed doses of α particles with various energies (3-10 MeV) transported in cells (cell radius RC = 10 μm, nucleus radius RN = 5 μm). Then, the result were compared with the S values (SN←N, SN←Cy, and SN←CS) derived using the medical internal radiation dose (MIRD) method to demonstrate the feasibility of Monte Carlo simulations. Finally, the energy deposition of the delayed particles of 9C-ions generated at three sites (i.e., on the surface and in the cytoplasm and nucleus of the V79 cell model) during their transport in targets was simulated, and the result ing cell surviving fraction was analyzed. Results Monte Carlo and MIRD method yielded differences in S values of 1.91%-4.95% for SN←N (nucleus to nucleus), 1.48%-5.11% for SN←Cy (cytoplasm to nucleus), and -1.99% to 0.80% for SN←CS(surface to nucleus), indicating highly consistent S values derived using both method(differences < 6%). When a 9C-ion decayed on the surface of the V79 cell model and the produced secondary particles entered the cell, the average endonuclear absorbed dose was 10-2 Gy orders of magnitude, with a cell surviving fraction of about 88%. In the case where decay occurred in the cytoplasm, the cell surviving fraction was about 80%. However, when the 9C ion decayed in the nucleus, α particles had short ranges and deposited most of their energy in the cell (mean endonuclear absorbed dose: 0.1 Gy). In this case, severe cell damage was induced, with the cell surviving fraction reducing to about 53%. Conclusions 9C-ions emit secondary charged particles due to decay, among which α particles cause great damage to cells when entering the nucleus and trigger evident biological effects. |
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