| Liu Yujie,Wang Jun,Li Keqin,et al.Effects of 2 650 MHz radiofrequency radiation on the behavior and hippocampal neurotransmitter release of mice[J].Chinese Journal of Radiological Medicine and Protection,2024,44(5):354-360 |
| Effects of 2 650 MHz radiofrequency radiation on the behavior and hippocampal neurotransmitter release of mice |
| Received:December 25, 2023 |
| DOI：10.3760/cma.j.cn112271-20231225-00221 |
| KeyWords:Radiofrequency radiation Cognition Social behavior Emotion Neurotransmitter |
| FundProject: |
| Author Name | Affiliation | E-mail | | Liu Yujie | College of Life Science and Engineering, Foshan University, Foshan 528225, China
Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences of the PLA Academy of Military Science, Beijing 100850, China | | | Wang Jun | Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences of the PLA Academy of Military Science, Beijing 100850, China | | | Li Keqin | College of Life Science and Engineering, Foshan University, Foshan 528225, China
Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences of the PLA Academy of Military Science, Beijing 100850, China | | | Chang Chenxu | Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences of the PLA Academy of Military Science, Beijing 100850, China | | | Liu Ying | Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences of the PLA Academy of Military Science, Beijing 100850, China | | | Zuo Hongyan | Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences of the PLA Academy of Military Science, Beijing 100850, China | | | Li Yang | Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences of the PLA Academy of Military Science, Beijing 100850, China | | | Yang Hong | College of Life Science and Engineering, Foshan University, Foshan 528225, China | | | Hao Yanhui | Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences of the PLA Academy of Military Science, Beijing 100850, China | | | Deng Hua | College of Life Science and Engineering, Foshan University, Foshan 528225, China | denghua@fosu.edu.cn |
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| Abstract:: |
| Objective To investigate the effects of 2 650 MHz radiofrequency (RF) exposure on the behavior and neurotransmitter release of mice. Methods Adult male C57BL/6N mice were divided into a normal control (CON) group and a radiofrequency radiation (RFR) group using the random number table method. The mice in the RFR group were subjected to single-dose whole-body exposure to a uniform 2 650 MHz RF electromagnetic field for 3 h. During the RF exposure, the field strength in the effective working area of the RF radiation platform was measured using an electromagnetic radiation analyzer, and the changes in the anal temperature of the mice were monitored using an optical fiber thermometer. Moreover, the changes in the cognition, social interaction, and emotion of the mice were determined through the new object recognition test, social preference test, and open field test. Finally, the changes in the hippocampal neurotransmitter release levels of the mice were detected using microdialysis sampling and mass spectrometry, and the changes in the hippocampal tissue structure and ultrastructure were observed via microscopy. Results Under the test conditions, RF radiation improved the anal temperature of the mice, with a maximum increasing amplitude of 0.61℃, falling within the range of thermal safety. The mice in the RFR group experienced a significant decrease in the frequency and time for exploring new objects (t=4.50, 2.53, P＜0.05) in the new object recognition test, a significant decrease in the frequency (t=0.08, P＜0.01) and time (t=0.03, P＜0.05) for exploring other mice in the social preference test, and no significant change in the frequency and time for exploring the central area (P > 0.05) in the open field test. Compared to the CON group, the RFR group showed an increase in the release of 5-hydroxytryptamine (5-HT) (t=-2.56, P＜0.05) and a decrease in the release of acetylcholine (ACh) (t=2.21, P＜0.05), no significant difference in the release of glutamate (Glu) and γ-aminobutyric acid (GABA) (P > 0.05), and no evident damage to the hippocampal tissue and structure and synaptic ultrastructure. Conclusions 2 650 MHz RF radiation may induce cognitive impairment and abnormal social preference in mice, which is attributed to neuronal dysfunctions and neurotransmitter release disorders under RF exposure. |
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