| Tian Zhuang,He Qi,Qiao Xuan,Li Lintao,Hu Xuan,Quan Xiaoxiao,Ye Tong,Gan Hui,Wu Zhuona,Gu Ruolan,Zhu Xiaoxia,Sun Yunbo,Liu Shuchen,Dou Guifang,Meng Zhiyun.Development and characterization of a decontamination film for radionuclide-contaminated wound[J].Chinese Journal of Radiological Medicine and Protection,2024,44(4):247-254 |
| Development and characterization of a decontamination film for radionuclide-contaminated wound |
| Received:November 02, 2023 |
| DOI：10.3760/cma.j.cn112271-20231121-00181 |
| KeyWords:Chelating agent Decontamination film Radioactive contamination |
| FundProject: |
| Author Name | Affiliation | E-mail | | Tian Zhuang | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | He Qi | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Qiao Xuan | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Li Lintao | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Hu Xuan | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Quan Xiaoxiao | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Ye Tong | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Gan Hui | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Wu Zhuona | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Gu Ruolan | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Zhu Xiaoxia | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Sun Yunbo | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Liu Shuchen | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Dou Guifang | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Meng Zhiyun | Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | mengzhiyun@vip.163.com |
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| Abstract:: |
| Objective To develop a decontamination film for radionuclide contamination and to examine its physical properties, nuclide removal effect, and safety. Method The decontamination film was prepared using sodium alginate and chitosan as matrix film, where a chelating agent formulation was loaded. The dissolution properties of the decontamination film were determined by placing it into normal saline. Its fracture stress and strain were measured using a tensile machine. A DTPA-5Na-based matrix film group, prepared using saline, matrix film, and 1% diethylenetriaminepentaacetic acid pentasodium salt (DTPA-5Na), served as the control group. Then, the effects of the decontamination film on the removal of uranium, cesium, cobalt, cerium, and strontium were examined on the intact skin and wound model of guinea pigs. A colorimetric assay-the methyl thiazolyl tetrazolium (MTT) assay-was employed to determine the toxicity of the decontamination film's leach liquor for clone 929 (L929) fibroblasts. The decontamination film's leach liquor was injected into Kunming (KM) mice to test its acute systemic toxicity. The skin irritation of the decontamination film was determined by covering of the film on the backs of New Zealand rabbits. Results The decontamination film exhibited a formation time of 1.5 min, dissolution rates of (134.96±3.49)%, fracture stress of (393.88±53.53) kN/m2, and fracture strain of (163.00%±35.29)%. The decontamination film removed (95.38±0.23)% of uranium and (96.57±0.49)% of cesium from the intact skin of guinea pigs. Furthermore, it removed (92.16±0.52)% of uranium, (90.44±1.16)% of cesium, (92.03±0.87)% of strontium, (92.79±0.51)% of cobalt, and (92.85±0.82)% of cerium from the wound model, with the decontamination rates all higher than those of normal saline and the 1% DTPA-5Na-based matrix film group (t = 3.81 - 4 498.55, P < 0.001). The safety evaluation tests indicated that the decontamination film met the national standard for the biological evaluation of medical devices. Conclusions The decontamination film, which can be formed swiftly and effectively remove a variety of nuclides with high safety, is suitable for the decontamination of the intact skin or wounds of personnel subjected to radionuclide contamination. It is expected that the decontamination film will provide a safety barrier for staff working in nuclear-contaminated areas. |
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