Yi Ruhan,Liu Mengmeng,Chen Jie,Li Chen,Gao Ling,Liu Qingjie.Role of senescence-associated secretory phenotype-related premature senescence in ionizing radiation-induced damage to vascular endothelial cells[J].Chinese Journal of Radiological Medicine and Protection,2024,44(3):240-246
Role of senescence-associated secretory phenotype-related premature senescence in ionizing radiation-induced damage to vascular endothelial cells
Received:July 18, 2023  
DOI:10.3760/cma.j.cn112271-20230718-00005
KeyWords:Senescence-associated secretory phenotype (SASP)  Cellular senescence  Vascular endothelial cell  Ionizing radiation
FundProject:北京市自然科学基金(7162139,7202137);国家自然科学基金(31570852)
Author NameAffiliationE-mail
Yi Ruhan Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China  
Liu Mengmeng Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China  
Chen Jie Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China  
Li Chen Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China  
Gao Ling Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China gaoling@nirp.chinacdc.cn 
Liu Qingjie Key Laboratory of Radiological Protection and Nuclear Emergency, China CDC, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China  
Hits: 469
Download times: 158
Abstract::
      Radiation-induced damage to vascular endothelium is a major complication of radiotherapy and a primary cause of morbidity and mortality in the population exposed to radiation. Ionizing radiation-induced cellular senescence serves as a critical factor in damage to vascular endothelial cells. Therefore, understanding the mechanisms of cellular senescence caused by senescence-associated secretory phenotype (SASP), as well as its role in ionizing radiation-induced damage to vascular endothelial cells, is significant for preventing and treating ionizing radiation-induced damage to vascular endothelial cells. In this study, the relationship between SASP-related premature senescence and this ionizing radiation-induced damage was explored from the following aspects: the mechanisms behind ionizing radiation-induced damage to vascular endothelial cells, ionizing radiation-induced cellular senescence, and the role of SASP-related premature senescence in the ionizing radiation-induced damage to vascular endothelial cells, as well as potential targets.
HTML  View Full Text  View/Add Comment  Download reader
Close

Copyright©    Editorial Office of Chinese Journal of Radiological Medicine and Protection    

Beijing ICP No. 05020547 -2

Address: 2 Xinkang Street, Dewai, Beijing 100088, China

Telephone:010-62389620; Email:cjrmp@cjrmp.sina.net

Technical Support:Beijing E-tiller CO.,LTD.

Visitors:9107672  On-line:0

v
Scan QR Code
&et=A31A26E85506B300824F82FDB7D09075EA45A4D079CF5BE20EB93236C18876EBBEC8ADFC5C362BD613FD4E9A6F9D03815D7D512ED93D8A238064A56980617DAE7A9D7BDC8CE4865ED569D708EBAB2355A0532CB16F4A9E709950362FD5380806C25E5567B281F098C03C951DB83D9F67C7EADAE81A57770E8058EC7A537D897C1907CC7A05F600C8940443DE23994D52191DF442F6E223AC&pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=D4D466D60FDC1A5A&jid=5E4353813E091AB841B02B880782B82C&yid=B80136CCD8DCBAA1&aid=&vid=&iid=38B194292C032A66&sid=C812B90E96151014&eid=28F9D9CF04F424FF&fileno=20240312&flag=1&is_more=0"> var my_pcid="A9DB1C13C87CE289EA38239A9433C9DC"; var my_cid="D4D466D60FDC1A5A"; var my_jid="5E4353813E091AB841B02B880782B82C"; var my_yid="B80136CCD8DCBAA1"; var my_aid="";