| Meng Xi,Sun Hongfu,Huang Wei.Progress in the application of PD-(L)1 PET-targeted nuclide probes for tumor immunotherapy-related studies[J].Chinese Journal of Radiological Medicine and Protection,2024,44(2):158-162 |
| Progress in the application of PD-(L)1 PET-targeted nuclide probes for tumor immunotherapy-related studies |
| Received:July 03, 2023 |
| DOI：10.3760/cma.j.cn112271-20230703-00223 |
| KeyWords:programmed death receptor-1/programmed death receptor-ligand 1 Molecular imaging Positron emission computed tomography tracer Immunotherapy |
| FundProject: |
| Author Name | Affiliation | E-mail | | Meng Xi | Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Sun Hongfu | Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | | | Huang Wei | Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China | alvinbird@163.com |
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| Abstract:: |
| Immunotherapy has entered the clinical treatment for various tumors, among which the blockade therapy of PD-1/PD-L1 immune checkpoint is currently the most important tumor immunotherapy method. At present, immunohistochemical method are used in clinical practice to detect PD-L1 expression in tumor patients and screen for indications. However, this method is constrained by factors such as heterogeneity, dynamic changes in PD-L1 expression, and limited sample collection. PD-(L)1 PET imaging utilizes radiolabeled molecules to non-invasively assess PD-(L)1 expression in space and time, and complementary use with IHC has theoretically incomparable advantages. This article reviews the latest progress in the PD-(L)1 probe molecular imaging principles, clinical research and existing problems. |
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