| Zeng Lijing,Xia Huang,Chen Yuxin,et al.Advances in research on radiation-induced brain injury[J].Chinese Journal of Radiological Medicine and Protection,2024,44(1):65-71 |
| Advances in research on radiation-induced brain injury |
| Received:July 06, 2023 |
| DOI：10.3760/cma.j.cn112271-20230706-00227 |
| KeyWords:Radiation-induced brain injury Radiotherapy Astrocyte Gut microbiota |
| FundProject:国家自然科学基金面上项目(82173452);福建医科大学附属协和医院优秀青年人才培育项目(2022XH034);福建医科大学大学生创新创业训练计划资助项目(YX2023009) |
| Author Name | Affiliation | E-mail | | Zeng Lijing | Department of Radiation Oncology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China
School of Medical Imaging of Fujian Medical University, Fuzhou 350122, China | | | Xia Huang | Department of Radiation Oncology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China | | | Chen Yuxin | School of Medical Imaging of Fujian Medical University, Fuzhou 350122, China | | | Lin Peiyue | School of Medical Imaging of Fujian Medical University, Fuzhou 350122, China | | | Yang Jing | School of Medical Imaging of Fujian Medical University, Fuzhou 350122, China | | | Zeng Wenyi | School of Medical Imaging of Fujian Medical University, Fuzhou 350122, China | | | Li Xiaobo | Department of Radiation Oncology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China | | | Xu Benhua | Department of Radiation Oncology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China | | | Zheng Rong | Department of Radiation Oncology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors, Clinical Research Center for Radiology and Radiotherapy of Fujian Province (Digestive, Hematological and Breast Malignancies), Fuzhou 350001, China | Zhengrrong@outlook.com |
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| Abstract:: |
| Radiotherapy can cause functional and morphological changes in the brain tissues of patients with primary or metastatic malignant brain tumors, leading to radiation-induced brain injury. However, the pathogenesis of radiation-induced brain injury has not yet been unanimously determined, and its research advances and treatment protocols are yet to be elucidated and improved. In this study, we explore the pathogenesis of radiation-induced brain injury from the perspective of vascular injury, inflammatory reactions, neuronal dysfunction, glial cell injury, and gut microbiota and reviewed the advances in research on its treatment and prevention. The purpose is to provide a reference and theoretical basis for the research and clinical diagnosis and treatment of radiation-induced brain injury. |
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