| Zhou Yongchun,Sun Xianglu,Wu Huan,Sun Nan,Li Wei,Han Yang,Deng Hu,Xie Lingxiao,Zhang Lei,Fu Shiwei,Jiang Hao.Effects of the deep inspiration breath-hold technique on cardiac dosimetry in internal mammary node irradiation with intensity-modulated radiation therapy for postoperative left breast cancer[J].Chinese Journal of Radiological Medicine and Protection,2023,43(12):979-985 |
| Effects of the deep inspiration breath-hold technique on cardiac dosimetry in internal mammary node irradiation with intensity-modulated radiation therapy for postoperative left breast cancer |
| Received:June 26, 2023 |
| DOI：10.3760/cma.j.cn112271-20230626-00209 |
| KeyWords:Deep inspiration breath-hold technique Internal mammary node irradiation Left breast cancer Radiation-induced heart disease Intensity-modulated radiation therapy |
| FundProject:国家自然科学基金(31200633);蚌埠医学院"512人才培育计划"项目(BY51201211);蚌埠医学院研究生科研创新计划项目(Byycx22050);蚌埠医学院第一附属医院新技术项目(2022164) |
| Author Name | Affiliation | E-mail | | Zhou Yongchun | Department of Radiation Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China | | | Sun Xianglu | Department of Radiation Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China | | | Wu Huan | Mental Health Faculty of Bengbu Medical College, Bengbu 233000, China | | | Sun Nan | Department of Radiation Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China | | | Li Wei | Department of Radiation Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China | | | Han Yang | Department of Radiation Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China | | | Deng Hu | Department of Radiation Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China | | | Xie Lingxiao | Department of Radiation Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China | | | Zhang Lei | Department of Radiation Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China | | | Fu Shiwei | Department of Radiation Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China | | | Jiang Hao | Department of Radiation Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, China | jianghao1223@163.com |
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| Abstract:: |
| Objective To explore the effects of the deep inspiration breath-hold (DIBH) technique on cardiac dosimetry in internal mammary node irradiation with intensity-modulated radiation therapy (IMN-IMRT) for postoperative left breast cancer.Methods Totally 23 left breast cancer patients in the First Affiliated Hospital of Bengbu Medical College from Octorber 2021 to July 2022 receiving postoperative IMN-IMRT were enrolled in this study. The changes in dosimetric parameters for their heart and left anterior descending coronary artery (LAD) in the DIBH mode were observed, and the potential factors affecting DIBH effects were analyzed.Results Compared with the free breath (FB) mode, the DIBH mode manifested a heart volume decrease by 18% (t = 10.47, P < 0.001), a left lung volume increase by 42% (t = -14.55, P < 0.001), and significantly reduced dosimetric parameters (Dmean, Dmax, V5-V30) for the heart and LAD, exhibiting statistically significant differences (t=-13.38 to -3.30, P＜0.05). As indicated by the Pearson correlation analysis, the relative ratio of cardiac dose reduction was positively correlated with that of left lung expansion (r = 0.82, P < 0.001) and negatively correlated with the patient'age (r = -0.56, P = 0.005).Conclusions DIBH can effectively reduce the heart and LAD radiation doses in IMN-IMRT for postoperative left breast cancer and that the patient's age, and the DIBH effects might be affected by the vital capacity. |
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