| Luo Hui,Phyllis Zhang,Li Nan,Ke Chou,Yang Chengliang,Ma Leijie,Lei Hongchang,Mao Ronghu,Song Shuai,Ge Hong.Radiation chemistry effects on water molecules after ultra-high dose rate irradiation[J].Chinese Journal of Radiological Medicine and Protection,2023,43(11):900-905 |
| Radiation chemistry effects on water molecules after ultra-high dose rate irradiation |
| Received:March 26, 2023 |
| DOI：10.3760/cma.j.cn112271-20230326-00094 |
| KeyWords:Ultra-high dose rate irradiation Water molecular Radiation chemistry effects Free radical Lipid peroxidation |
| FundProject:国家自然科学基金(81773230);河南省科技攻关计划项目(212102310619) |
| Author Name | Affiliation | E-mail | | Luo Hui | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China | | | Phyllis Zhang | The University of Hong Kong, Hong Kong 999077, China | | | Li Nan | Faculty of Chemistry, Zhengzhou University, Zhengzhou 450001, China | | | Ke Chou | Faculty of Chemistry, Vienna University, Vienna 1010, Austria | | | Yang Chengliang | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China | | | Ma Leijie | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China | | | Lei Hongchang | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China | | | Mao Ronghu | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China | | | Song Shuai | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China | | | Ge Hong | Department of Radiation Oncology, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China | zlyygehong0199@zzu.edu.cn |
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| Abstract:: |
| Objective To compare the radiation chemistry effects on water molecules after ultra-high dose rate (FLASH) and conventional irradiation.Methods Both FLASH and conventional irradiation were applied to ultrapure water, with the hydroxyl radical yield in the homogeneous phase detected using electron paramagnetic resonance (EPR) and the hydrogen peroxide (H2O2) yield in the diffusion phase analyzed uuxing fluorescence probe. The liposome model was then established to investigate the radiation chemistry effect of FLASH and conventional irradiation in inducing lipid peroxidation.Results Radiation chemistry reactions were observed in water molecules after irradiation. In the homogeneous phase, the yield of free radicals using FLASH irradiation is similar to those from conventional irradiation (P>0.05). In the diffusion phase, the amount of H2O2 produced by FLASH irradiation was significantly lower than those from conventional irradiation (t=0.49-12.81, P<0.05). The liposome model confirmed that conventional irradiation could significantly induce lipid peroxidation through the radiation chemistry effect in water molecules as compared with FLASH irradiation (t=0.31-11.73, P<0.05).Conclusions The radiation chemistry effect in water molecules after FLASH irradiation was significantly lower than that from conventional irradiation. This could be one of the mechanisms of FLASH effect. |
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