| Zheng Xuan,Wang Hongzhi,Dong Dezuo,Zhu Xianggao,Geng Jianhao,Li Shuai,Song Maxiaowei,Zhang Yangzi,Liu Zhiyan,Cai Yong,Li Yongheng,Wang Weihu.Effectiveness and safety of the second-course radiotherapy for unresectable colorectal cancer liver metastases[J].Chinese Journal of Radiological Medicine and Protection,2023,43(11):873-880 |
| Effectiveness and safety of the second-course radiotherapy for unresectable colorectal cancer liver metastases |
| Received:July 10, 2023 |
| DOI：10.3760/cma.j.cn112271-20230710-00231 |
| KeyWords:Colorectal cancer liver metastasis Second-course radiotherapy Effectiveness Adverse event |
| FundProject:北京市科技计划首都临床特色应用研究(Z181100001718192);北京市医院管理中心"登峰"人才培养计划(DFL20220902) |
| Author Name | Affiliation | E-mail | | Zheng Xuan | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Wang Hongzhi | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Dong Dezuo | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Zhu Xianggao | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Geng Jianhao | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Li Shuai | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Song Maxiaowei | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Zhang Yangzi | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Liu Zhiyan | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Cai Yong | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Li Yongheng | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | | | Wang Weihu | Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China | wangweihu88@163.com |
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| Abstract:: |
| Objective To analyze the effectiveness and safety of the second course radiotherapy for unresectable colorectal cancer liver metastases.Methods We retrospectively collected the data of 28 patients with unresectable colorectal cancer liver metastases who received the second course radiotherapy at Peking University Cancer Hospital and Institute from 2017 to 2023, to analyze the feasibility of re-irradiation.Results For the 28 patients, the median follow-up time after re-irradiation was 20.2 months. The median time interval between the first- and second-course radiotherapy was 11.1 months. The median biologically effective doses of the first- and second-course radiotherapy were 100 Gy and 96 Gy, respectively. Stereotactic body radiotherapy was administered to 25 patients (89.3%) during the first course and 24 patients (85.7%) during the second course of radiotherapy. The mean equivalent dose in 2 Gy fractions to the normal liver was 10.1 Gy in the first-course radiotherapy and 7.9 Gy in the second-course radiotherapy. The complete response rate, partial response rate, and objective response rate after re-irradiation were 54.5%, 18.2%, and 72.7%, respectively. After re-irradiation, the 2-year cumulative local failure rate was 17.0% when calculated based on patients and 15.1% when calculated based on lesions, the 1-year progression-free survival rate was 27.4%, and the 3-year overall survival rate was 46.7%. The second-course radiotherapy was well tolerated, with most patients (75.0%) experiencing grade 1-2 acute adverse reactions and only one case (3.6%) experiencing grade 3 acute adverse events.Conclusions Second course radiotherapy is an effective and safe treatment approach for selected patients with unresectable colorectal cancer liver metastases. |
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