| Shang Shiyu,Gao Xianshu,Lyu Feng,et al.Assessment of 3D-printed tissue compensators for superficial tumor X-ray radiation compensation[J].Chinese Journal of Radiological Medicine and Protection,2023,43(7):518-523 |
| Assessment of 3D-printed tissue compensators for superficial tumor X-ray radiation compensation |
| Received:February 23, 2023 |
| DOI：10.3760/cma.j.cn112271-20230223-00050 |
| KeyWords:3D printing|Tissue compensator|Superficial tumor |
| FundProject:国家自然科学基金(82271771);北京市自然科学基金(7182164);中央高水平医院临床科研业务费(北京大学第一医院科研种子基金项目,2023SF04) |
| Author Name | Affiliation | E-mail | | Shang Shiyu | Graduate School, Hebei North University, Zhangjiakou 075000, China | | | Gao Xianshu | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | doctorgaoxs@126.com | | Lyu Feng | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Gao Yan | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Shang Zhaocai | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Ren Xueying | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Chen Jiayan | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Liu Peilin | Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China | | | Zhang Min | Department of Radiation Oncology, Peking University People's Hospital, Beijing 100044, China | |
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| Abstract:: |
| Objective To investigate the advantage of three dimensional (3D)-printed tissue compensators in radiotherapy for superficial tumors at irregular sites. Methods A subcutaneous xenograft model of prostate cancer in nude mice was established. Mice were randomly divided into no tissue compensator group(n=6), common tissue compensator group(n=6), and 3D-printed tissue compensator group(n=6). Computed tomography (CT) images of nude mice in the 3D-printed tissue compensator group were acquired. Compensator models were made using polylactic acid, and material properties were evaluated by measuring electron density. CT positioning images of the three groups after covering the corresponding tissue compensators were acquired to delineate the gross tumor volume (GTV). Nude mice in the three groups were irradiated with 6 MV X-rays at the prescribed dose. The prescribed dose for the three groups was 1 500 cGy. The dose distribution in the GTV of the three groups was calculated and compared using the analytical anisotropic algorithm in the Eclipse 13.5 treatment planning system. The metal-oxide-semiconductor field-effect transistor was used to verify the actual dose received on the skin surface of nude mice. Results The air gap in the 3D-printed tissue compensator group and the common tissue compensator group was 0.20±0.07 and 0.37±0.07 cm3, respectively (t=4.02, P<0.01). For the no tissue compensator group, common tissue compensator group, and 3D-printed tissue compensator group, the D95% in the target volume was (1 188.58±92.21), (1 369.90±146.23), and (1 440.29±45.78) cGy, respectively (F=9.49, P<0.01). D98% was (1 080.13±88.30), (1 302.76±158.43), and (1 360.23±48.71) cGy, respectively (F=11.17, P<0.01). Dmean was (1 549.08±44.22), (1 593.05±65.40), and (1 638.87±40.83) cGy, respectively (F=4.59, P<0.05). The measured superficial dose was (626.03±26.75), (1 259.83±71.94), and (1 435.30±67.22) cGy, respectively (F=263.20, P<0.001). The percentage variation in tumor volume growth after radiation was not significantly different between the common tissue compensator group and the 3D-printed tissue compensator group (P>0.05). Conclusions 3D-printed tissue compensators fit well to the body surface, which reduces air gaps, effectively increases the dose on the body surface near the target volume, and provides ideas for radiotherapy for superficial tumors at some irregular sites. |
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