| Tang Jing,Ma Jixiang,Li Zhiyuan,et al.Simulation calculation of relative biological effectiveness based on DNA double strand break clusters[J].Chinese Journal of Radiological Medicine and Protection,2023,43(7):489-498 |
| Simulation calculation of relative biological effectiveness based on DNA double strand break clusters |
| Received:February 20, 2023 |
| DOI：10.3760/cma.j.cn112271-20230220-00039 |
| KeyWords:DNA double strand break clusters|Relative biological effectiveness|Density-based spatial clustering of applications with noise algorithm |
| FundProject:国家自然科学基金(11605160) |
| Author Name | Affiliation | E-mail | | Tang Jing | Shanxi Provincial Key Laboratory for Biomedical Imaging and Big Data, North University of China, Taiyuan 030051, China
School of Software, North University of China, Taiyuan 030051, China | | | Ma Jixiang | School of Information and Communication Engineering, North University of China, Taiyuan 030051, China | | | Li Zhiyuan | Shanxi Provincial Key Laboratory for Biomedical Imaging and Big Data, North University of China, Taiyuan 030051, China | | | Li Jie | Department of Radiation Oncology, Shanxi Provincial Cancer Hospital, Taiyuan 030013, China | | | Zhang Pengcheng | Shanxi Provincial Key Laboratory for Biomedical Imaging and Big Data, North University of China, Taiyuan 030051, China
School of Information and Communication Engineering, North University of China, Taiyuan 030051, China | zhangpc198456@163.com |
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| Abstract:: |
| Objective To obtain the relative biological effectiveness (RBE) of DNA double strand breaks (DSB) clusters by tracing the mechanism of radiated DNA damage, and explore the relationship among the biological effectiveness of DNA damage, chromosomal aberrations and germ cell death. Methods Taking low-energy electrons, protons, and α particles as the research objects, this study simulated the process that cell nuclei were exposed to particle radiation using a radiation-related physicochemical model. On the ground of the DSB density-based spatial clustering of applications with noise (DBSCAN) algorithm, the DSB cluster classification method was improved to weaken the connection between the DSBs and the random distribution assumptions of energy depositions during the simulation. In this manner, the DSB clusters can be much closer to a non-random distribution. Furthermore, this study obtained the yields of DSB clusters and proposed a method to calculate the RBE values of DSB clusters. Results The calculated RBE value (12.29) of DSB clusters of 2 MeV α particles was similar to the experimental RBE values of chromosomal fragments (15.3±5.9) and cell survival (14.7±5.1). Conclusions After high-LET ionizing radiation, unlike the single DSB, the RBE of DSB clusters was similar to that of chromosomal aberration and cell survival. |
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