| Yu Weiyue,Hong Bing,Lu Peng,Liang Lizhen,Chen Ni.Computation of relative biological effectiveness of low-energy electrons release in gadolinium neutron capture therapy based on microdosimetry[J].Chinese Journal of Radiological Medicine and Protection,2023,43(5):373-378 |
| Computation of relative biological effectiveness of low-energy electrons release in gadolinium neutron capture therapy based on microdosimetry |
| Received:August 22, 2022 |
| DOI：10.3760/cma.j.112271-20220822-00338 |
| KeyWords:157GdNCT Geant4 Microdosimetry Relative Biological Effectiveness |
| FundProject:安徽医科大学基础与临床合作研究提升计划项目(2019xkjT011);合肥综合性国家科学中心能源研究院重大培育项目(21KZS202,21KZS208);安徽高校协同创新项目(GXXT-2022-004) |
| Author Name | Affiliation | E-mail | | Yu Weiyue | Teaching and Research Section of Nuclear Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China | | | Hong Bing | Institute of Energy, Hefei Comprehensive National Science Center, Anhui Energy Laboratory, Hefei 230031, China | | | Lu Peng | Institute of Energy, Hefei Comprehensive National Science Center, Anhui Energy Laboratory, Hefei 230031, China | | | Liang Lizhen | Institute of Energy, Hefei Comprehensive National Science Center, Anhui Energy Laboratory, Hefei 230031, China | | | Chen Ni | Teaching and Research Section of Nuclear Medicine, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, China | chenni@ahmu.edu.cn |
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| Abstract:: |
| Objective To calculate the relative biological effectiveness (RBE) value of the released low-energy electrons in gadolinium neutron capture therapy (157GdNCT) based on microdosimetry. Methods The Monte Carlo (MC) code Geant4-DNA package was used to simulate the energy deposition distribution and microdosimetry parameters of low-energy electrons released during gadolinium neutron capture treatment in different sensitive target volumes and physical models on track structures. On this basis, RBE value was obtained based on the microdosimetry kinetic model (MKM). Results The low-energy electron RBE value was highly variable in different sensitive target volumes and decreases with increasing sensitive target volumes. With 6-nm-diameter sensitive target as reference, RBE value was 1.77 for 6-nm diameter, 1.53 for 10 nm diameter with percentage difference 13%, and 1.40 for 15-nm diameter with percentage difference of 21%, respectively. The effect of different Geant4-DNA physical models on the RBE of low-energy electrons was small. Using the RBE value of 1.53 for physical model option2 as reference, the RBE values of option6 and option7 were 1.49 and 1.52, respectively, with the percentage differences of 2.6% and 0.6%, respectively. Conclusions The RBE values of low energy electrons released by 157GdNCT in different sensitive target volumes and physical models were calculated by MKM to be 1.40-1.77. |
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