| Ao Xingkun,Yan Ziyan,Gu Yongqing.The role and treatment strategy of epithelial-mesenchymal transition in radiation-induced pulmonary fibrosis[J].Chinese Journal of Radiological Medicine and Protection,2023,43(4):307-313 |
| The role and treatment strategy of epithelial-mesenchymal transition in radiation-induced pulmonary fibrosis |
| Received:November 11, 2022 |
| DOI：10.3760/cma.j.cn112271-20221111-00443 |
| KeyWords:Radiation-induced pulmonary fibrosis Epithelial-mesenchymal transition Signal transduction Epigenetics Drug therapy |
| FundProject: |
| Author Name | Affiliation | E-mail | | Ao Xingkun | Graduate Collaborative Training Base of Academy of Military Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China | | | Yan Ziyan | Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China | | | Gu Yongqing | Graduate Collaborative Training Base of Academy of Military Sciences, Hengyang Medical School, University of South China, Hengyang 421001, China | yqgu96@163.com |
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| Abstract:: |
| Radiation-induced pulmonary fibrosis (RIPF) is one of the most serious late complications after nuclear radiation accident, bone marrow transplantation pretreatment and thoracic tumor radiotherapy. The formation process of RIPF is complicated and the pathogenesis has not been fully elucidated. Recent studies have shown that radiation-induced epithelial-mesenchymal transition (EMT) of lung epithelial cells is an indispensable segment of RIPF. This article reviews the role of radiation-induced lung EMT in the occurrence and development of RIPF and related drugs with EMT as a potential therapeutic target, providing ideas for the development of therapeutic drugs for RIPF in the future. |
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