| Zhou Shengxiang,Tang Yan,Tang Peng,Wang Yangcan,Deng Shuxiang,Shen Minxue,Yang Fei.Correlation analysis between uranium exposure and renal injury[J].Chinese Journal of Radiological Medicine and Protection,2023,43(4):276-283 |
| Correlation analysis between uranium exposure and renal injury |
| Received:November 29, 2022 |
| DOI：10.3760/cma.j.cn112271-20221129-00462 |
| KeyWords:Plasma uranium Renal injury Case-control Conditional logistic regression |
| FundProject:湖南省重点研发项目(2022SK2089);湖湘青年人才计划项目(2021RC3107) |
| Author Name | Affiliation | E-mail | | Zhou Shengxiang | The Key Laboratory of Typical Environmental Pollution and Health Hazards of Hunan Province, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China | | | Tang Yan | The Key Laboratory of Typical Environmental Pollution and Health Hazards of Hunan Province, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China | | | Tang Peng | The Key Laboratory of Typical Environmental Pollution and Health Hazards of Hunan Province, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China | | | Wang Yangcan | The Key Laboratory of Typical Environmental Pollution and Health Hazards of Hunan Province, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China | | | Deng Shuxiang | The Key Laboratory of Typical Environmental Pollution and Health Hazards of Hunan Province, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China | | | Shen Minxue | Hunan Provincial Key Laboratory of Clinical Epidemiology, Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha 410000, China | | | Yang Fei | The Key Laboratory of Typical Environmental Pollution and Health Hazards of Hunan Province, School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, China | phfyang@usc.edu.cn |
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| Abstract:: |
| Objective To analyze the relationship between plasma uranium concentration and renal injury.Methods A case-control study was conducted in Hunan province, involving 102 renal injury cases and 102 matched controls. The association between plasma uranium concentration and renal injury was analyzed using conditional logistic regression models, and the dose-response relationship was analyzed through restricted cubic spline regression. The linear regression model and Spearman correlation were used to analyze the association between plasma uranium concentration and renal injury indicators.Results The median of plasma uranium concentration was 8.94 ng/L in all subjects and 10.19 ng/L in the case group. The plasma uranium may be a risk factor for renal injury, with a dose-response relationship between the both representing nonlinear association (χ2=5.15, P<0.05). The risk of renal injury was 4.21 times higher in the group exposed to highest uranium concentration than that in the group exposed to lowest uranium concentration. Plasma uranium concentration was closely related to glomerular filtration rate, serum creatinine and β2-microglobulin (r=0.211, -0.142, 0.195, P<0.05).Conclusions The plasma uranium concentration is significantly associated with the renal injury, which may provide epidemiology evidence for the prevention of renal injury. |
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