| Li Yuanyuan,Wang Miao,Jin Feng,et al.Effects of Onodera's prognostic nutritional index on the prognosis of locally advanced oropharyngeal squamous cell carcinoma after induction chemotherapy followed by sequential chemoradiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2023,43(4):256-262 |
| Effects of Onodera's prognostic nutritional index on the prognosis of locally advanced oropharyngeal squamous cell carcinoma after induction chemotherapy followed by sequential chemoradiotherapy |
| Received:October 09, 2022 |
| DOI：10.3760/cma.j.cn112271-20221009-00404 |
| KeyWords:Prognostic nutritional index Oropharyngeal squamous cell carcinoma Human papilloma virus Intensity-modulated radiotherapy Prognosis |
| FundProject:贵州省卫健委科学技术基金项目(gzwkj2023-119) |
| Author Name | Affiliation | E-mail | | Li Yuanyuan | Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China
Department of Head and Neck Oncology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550003, China | | | Wang Miao | Department of Head and Neck Oncology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550003, China | | | Jin Feng | Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China
Department of Head and Neck Oncology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550003, China | jinf8865@yeah.net | | Wu Weili | Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China
Department of Head and Neck Oncology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550003, China | | | Long Jinhua | Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China
Department of Head and Neck Oncology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550003, China | | | Luo Xiuling | Department of Oncology, Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China
Department of Head and Neck Oncology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550003, China | | | Gong Xiuyun | Department of Head and Neck Oncology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550003, China | | | Chen Xiaoxiao | Department of Head and Neck Oncology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550003, China | |
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| Abstract:: |
| Objective To explore the effects of Onodera's prognostic nutritional index (PNI) on the prognosis of locally advanced oropharyngeal squamous cell carcinoma (LA-OPSCC) after induction chemotherapy followed by sequential chemoradiotherapy.Methods A retrospective analysis was conducted on the clinical data of 52 LA-OPSCC patients receiving induction chemotherapy followed by sequential chemoradiotherapy in The Affiliated Cancer Hospital of Guizhou Medical University during 2014-2018. The PNI values of all the patients at different treatment phases were statistically analyzed, and the ROC curve was employed to determine the optimal critical value of PNI. The patients in this study were divided into a well-nourished group (n = 27) and a poorly-nourished group (n = 25). The Kaplan-Meier method was used for survival analysis. The Cox proportional hazards model was utilized to analyze the relationships between different nutritional status and prognosis. Clinical features and adverse reactions were compared between the two groups.Results The PNI values decreased significantly after radiotherapy, with an optimal critical value of 42.4. The 5-year overall survival (OS) and progression-free survival (PFS) of the well-nourished group (PNI ≥ 42.4) were 62.6% and 60.9%, respectively, which were significantly higher than those (30.1% and 29.7%) of the poorly-nourished group (PNI < 42.4, χ2 = 11.12, 5.74, P ＜ 0.05). The multivariate analysis showed that PNI was an independent prognostic factor for the OS after radiotherapy (HR = 2.752, 95％CI: 1.095-6.917, P = 0.031). The LA-OPSCC patients aged over 60 years or those who did not respond to induction chemotherapy accounted for a higher proportion of malnutrition after chemoradiotherapy (χ2= 4.89, 5.05, P ＜ 0.05).Conclusions PNI after radiotherapy can be used as a prognostic factor in the evaluation of LA-OPSCC patients receiving induction chemotherapy followed by sequential chemoradiotherapy. The LA-OPSCC patients aged over 60 years or those who do not respond to induction chemotherapy should receive more nutritional support during the chemoradiotherapy. |
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